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Mitochondrial permeability transition triggers the release of mtDNA fragments
Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent re...
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| Published in: | Cellular and molecular life sciences : CMLS 2004-12, Vol.61 (24), p.3100-3103 |
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| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c472t-15d4fc7a171eb02c111d6983a0afb26a441482c62bb4d79dfffe7c556cdc02b93 |
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| container_end_page | 3103 |
| container_issue | 24 |
| container_start_page | 3100 |
| container_title | Cellular and molecular life sciences : CMLS |
| container_volume | 61 |
| creator | Patrushev, M Kasymov, V Patrusheva, V Ushakova, T Gogvadze, V Gaziev, A |
| description | Fragments of mitochondrial DNA are released from mitochondria upon opening of the mitochondrial permeability transition pore. Cyclosporin A, an inhibitor of pore opening, completely prevented the release of mitochondrial fragments. Induction of mitochondrial permeability transition and subsequent release of the fragments of mitochondrial DNA could be one cause of genomic instability in the cell. |
| doi_str_mv | 10.1007/s00018-004-4424-1 |
| format | article |
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| identifier | ISSN: 1420-682X |
| ispartof | Cellular and molecular life sciences : CMLS, 2004-12, Vol.61 (24), p.3100-3103 |
| issn | 1420-682X 1420-9071 |
| language | eng |
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| source | Springer Nature; PubMed Central |
| subjects | Animals Cellular biology Cyclosporine - pharmacology DNA, Mitochondrial - metabolism Ion Channels - physiology Mice Mice, Inbred BALB C Mitochondria, Liver - drug effects Mitochondria, Liver - physiology Mitochondrial DNA Mitochondrial Membrane Transport Proteins Permeability |
| title | Mitochondrial permeability transition triggers the release of mtDNA fragments |
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