Integrative systems biology and networks in autophagy

The growing recognition that autophagy has important roles in many biological pathways, physiological systems, and infection and disease states necessitates a multidimensional perspective and systems-wide understanding of how autophagy is triggered or modulated by diverse stimuli. To delineate the n...

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Bibliographic Details
Published in:Seminars in immunopathology 2010-12, Vol.32 (4), p.355-361
Main Author: Ng, Aylwin C. Y.
Format: Article
Language:English
Subjects:
Animals
Autophagy
Autophagy - immunology
Bacterial infections
Biological and medical sciences
Biology
Biomedical and Life Sciences
Biomedicine
Crohn's disease
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gene expression
Genome, Human - immunology
Genome-Wide Association Study - methods
Genomes
Genomics
Humans
Immunology
Immunopathology
Internal Medicine
Kinases
Medical sciences
Models, Immunological
Polymorphism
Review
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Signal Transduction - immunology
Systems Biology - methods
Viruses
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Summary:The growing recognition that autophagy has important roles in many biological pathways, physiological systems, and infection and disease states necessitates a multidimensional perspective and systems-wide understanding of how autophagy is triggered or modulated by diverse stimuli. To delineate the nonlinearity and combinatorial complexity of biological networks and signaling pathways impinging on autophagy requires an integrative framework that brings together diverse information from genome-scale data (genomics, transcriptomics, proteomics, interactomics, functional RNAi screens) to dynamic time-series analyses and biochemical assays across a variety of biological and clinical contexts. We outline recent applications of genome-wide approaches to studying autophagy and highlight how some of these could be integrated to derive sub-networks that are more functionally focused. Viewed from a network perspective, the extensive interconnectivity between pathway systems converging on autophagy provides the essential foundation from which to systematically elucidate the regulatory nuances and crosstalks that orchestrate autophagic processes in different pathophysiological contexts.
ISSN:1863-2297
1863-2300
DOI:10.1007/s00281-010-0225-9