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Effects of astragalus polysaccharides on immunologic function of erythrocyte in chickens infected with infectious bursa disease virus
Abstract 160 Haline white chickens at 25 days old, negative for antibody to infectious bursa disease virus (IBDV), were randomly allocated into four groups. Chickens in groups 2–4 were infected with 0.3 ml IBDV at 26 days old. Chickens in groups 3 and 4 were injected respectively with 5 and 10 mg as...
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Published in: | Vaccine 2010-08, Vol.28 (34), p.5614-5616 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Abstract 160 Haline white chickens at 25 days old, negative for antibody to infectious bursa disease virus (IBDV), were randomly allocated into four groups. Chickens in groups 2–4 were infected with 0.3 ml IBDV at 26 days old. Chickens in groups 3 and 4 were injected respectively with 5 and 10 mg astragalus polysaccharide (APS) for 6 consecutive days from the first day of infection. At 21, 29, 32, 35 and 38 days old, the blood samples were taken from heart, and erythrocyte-C3b receptor rosette rate (E-C3b RR), erythrocyte-C3b immune complex rosette rate (E-ICRR), erythrocyte rosette forming enhancing rate (ERER) and erythrocyte rosette forming inhibitory rate (ERIR) were measured. The results showed that E-C3b RR and ERER significantly declined in chicken infected with IBDV ( p < 0.01); E-C3b RR, E-ICRR and ERER in groups 3 and 4 treated with APS were higher than that in groups 1 and 2 ( p < 0.01), the ERIR in groups 3 and 4 is similar to that in group 1. The results suggest that the immunological function of chicken erythrocytes declines after infected with IBDV and APS obviously enhances the immunological function of chicken erythrocytes. |
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ISSN: | 0264-410X 1873-2518 |
DOI: | 10.1016/j.vaccine.2010.06.025 |