In vitro interactions between amphotericin B and other antifungal agents and rifampin against Fusarium spp

Fusarium species are common hyaline soil saprophytes and plant pathogens that are opportunistic fungal pathogens of immunocompromised patients. The treatment for fusariosis remains uncertain with an unfavourable prognosis; new possibilities for treatment, such as various synergistic drug interaction...

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Bibliographic Details
Published in:Mycoses 2011-03, Vol.54 (2), p.131-136
Main Authors: Spader, T.B, Venturini, T.P, Cavalheiro, A.S, Mahl, C.D, Mario, D.N, Lara, V.M, Santurio, J, Alves, S.H
Format: Article
Language:English
Subjects:
Amphotericin B
Amphotericin B - pharmacology
Antifungal agents
Antifungal Agents - pharmacology
antifungal association
Drug Interactions
Fusarium
Fusarium - drug effects
Fusarium - physiology
Fusarium spp
Humans
Mycoses - microbiology
Rifampin
Rifampin - pharmacology
synergism
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Summary:Fusarium species are common hyaline soil saprophytes and plant pathogens that are opportunistic fungal pathogens of immunocompromised patients. The treatment for fusariosis remains uncertain with an unfavourable prognosis; new possibilities for treatment, such as various synergistic drug interactions, must be uncovered. In this study, we evaluated the in vitro interactions of amphotericin B with caspofungin, ketoconazole, 5-flucytosine, itraconazole, miconazole, rifampin, fluconazole, terbinafine and voriconazole against isolates of Fusarium spp. using the chequerboard method with interactions evaluated by fractional inhibitory concentration indices. The highest percentages of synergistic interactions were observed for the combinations of amphotericin B and caspofungin (68.7%), amphotericin B and rifampin (68.7%), amphotericin B plus 5-flucytosine (59.3%) and amphotericin B with voriconazole (37.5%). The pattern of susceptibility to antifungal agents among Fusarium species and their consequence on the effects of drug combinations are also discussed.
ISSN:0933-7407
1439-0507
DOI:10.1111/j.1439-0507.2009.01773.x