Functional analysis of a mitochondrial phosphopantetheinyl transferase (PPTase) gene pptB in Aspergillus fumigatus

The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located...

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Bibliographic Details
Published in:Fungal genetics and biology 2011-04, Vol.48 (4), p.456-464
Main Authors: Allen, Gethin, Bromley, Mike, Kaye, Sarah J., Keszenman-Pereyra, David, Zucchi, Tiago D., Price, Jaqueline, Birch, Mike, Oliver, Jason D., Turner, Geoffrey
Format: Article
Language:English
Subjects:
acyl carrier protein
Acyl Carrier Protein - metabolism
Aspergillus fumigatus
Aspergillus fumigatus - enzymology
Aspergillus fumigatus - genetics
Aspergillus fumigatus - physiology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
biosynthesis
Essential genes
genes
lysine
Microbial Viability
mitochondria
Mitochondria - enzymology
NpgA
pathogens
Phosphopantetheinyl transferase
PptA
PptB
Respiration
Siderophore
Substrate Specificity
Transferases (Other Substituted Phosphate Groups) - genetics
Transferases (Other Substituted Phosphate Groups) - metabolism
viability
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Summary:The mitochondrial phosphopantetheinyl transferase gene pptB of the opportunistic pathogen Aspergillus fumigatus has been identified and characterised. Unlike pptA, which is required for lysine biosynthesis, secondary metabolism, and iron assimilation, pptB is essential for viability. PptB is located in the mitochondria. In vitro expression of pptA and pptB has shown that PptB is specific for the mitochondrial acyl carrier protein AcpA.
ISSN:1087-1845
1096-0937
DOI:10.1016/j.fgb.2010.12.006