Plasma Levels of C-Telopeptide Pyridinoline Cross-Links of Type I Collagen and Osteocalcin in Chronic Periodontitis

This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention...

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Bibliographic Details
Published in:Inflammation 2011-06, Vol.34 (3), p.203-208
Main Authors: Özçaka, Özgün, Nalbantsoy, Ayşe, Bıçakçı, Nurgün, Köse, Timur, Buduneli, Nurcan
Format: Article
Language:English
Subjects:
Adult
Biomarkers - blood
Biomedical and Life Sciences
Biomedicine
Blood Chemical Analysis
Case-Control Studies
Chronic Periodontitis - blood
Collagen Type I - blood
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunology
Internal Medicine
Male
Middle Aged
Osteocalcin - blood
Pathology
Peptides - blood
Pharmacology/Toxicology
Radioimmunoassay
Reference Values
Rheumatology
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Summary:This study was planned to investigate whether chronic periodontitis patients exhibit different plasma concentrations of C-telopeptide pyridinoline cross-links of type I collagen (ICTP) and osteocalcin (OC) compared to the clinically healthy controls. Before initiation of any periodontal intervention, plasma samples and full-mouth clinical periodontal recordings were obtained from 58 otherwise healthy patients with chronic periodontitis and also from 47 systemically and periodontally healthy control subjects. Plasma ICTP levels were determined by radioimmunoassay and OC levels by enzyme-linked immunosorbent assay. Data were tested statistically using t test and ANOVA. The healthy control group exhibited significantly lower values in all clinical periodontal measurements ( P   0.05). Within the limits of this study, it may be suggested that plasma levels of ICTP and OC may not provide distinguishing data between chronic periodontitis patients and clinically healthy subjects.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-010-9225-0