Successful operation for mitral regurgitation in a patient with Gilbert’s syndrome

A 72-year-old woman complaining of dyspnea on effort was diagnosed as having mitral regurgitation (MR). Asymptomatic jaundice had initially been noticed during primary school, and an examination had shown hyperbilirubinemia. After the diagnosis of constitutional jaundice, she had remained well witho...

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Bibliographic Details
Published in:General thoracic and cardiovascular surgery 2011-05, Vol.59 (5), p.344-346
Main Authors: Minami, Hiroya, Asada, Tatsuro, Gan, Kunio, Yamada, Akitoshi, Yano, Yoshihiko
Format: Article
Language:English
Subjects:
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Bilirubin - blood
Biomarkers - blood
Cardiac Surgery
Cardiology
Case Report
DNA Mutational Analysis
Echocardiography, Transesophageal
Female
Gilbert Disease - blood
Gilbert Disease - complications
Gilbert Disease - diagnosis
Gilbert Disease - genetics
Glucuronosyltransferase - genetics
Glucuronosyltransferase - metabolism
Heart Valve Prosthesis Implantation
Humans
Medicine
Medicine & Public Health
Mitral Valve Insufficiency - diagnostic imaging
Mitral Valve Insufficiency - etiology
Mitral Valve Insufficiency - surgery
Mutation
Severity of Illness Index
Surgical Oncology
Thoracic Surgery
Treatment Outcome
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Summary:A 72-year-old woman complaining of dyspnea on effort was diagnosed as having mitral regurgitation (MR). Asymptomatic jaundice had initially been noticed during primary school, and an examination had shown hyperbilirubinemia. After the diagnosis of constitutional jaundice, she had remained well without further examination or medical treatment. Laboratory data showed a total serum bilirubin (TB) level of 12.2 mg/dl and a direct bilirubin level of 0.6 mg/dl. Transesophageal echocardiography showed severe MR, and we replaced the mitral valve. Postoperatively, genetic analyses identified constitutional jaundice as Gilbert’s syndrome with Y486D mutation. The TB level gradually decreased. Four years after operation she is doing well with moderate hyperbilirubinemia and a TB level of 5 mg/dl. She is free from heart failure.
ISSN:1863-6705
1863-6713
DOI:10.1007/s11748-010-0688-6