Association of genetic variants for susceptibility to obesity with type 2 diabetes in Japanese individuals

Aims/hypothesis In populations of East Asian descent, we performed a replication study of loci previously identified in populations of European descent as being associated with obesity measures such as BMI and type 2 diabetes. Methods We genotyped 14 single nucleotide polymorphisms (SNPs) from 13 ca...

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Bibliographic Details
Published in:Diabetologia 2011-06, Vol.54 (6), p.1350-1359
Main Authors: Takeuchi, F., Yamamoto, K., Katsuya, T., Nabika, T., Sugiyama, T., Fujioka, A., Isono, M., Ohnaka, K., Fujisawa, T., Nakashima, E., Ikegami, H., Nakamura, J., Yamori, Y., Yamaguchi, S., Kobayashi, S., Ogihara, T., Takayanagi, R., Kato, N.
Format: Article
Language:English
Subjects:
Adult
Aged
Asian Continental Ancestry Group - ethnology
Asian Continental Ancestry Group - genetics
Biological and medical sciences
Body fat
Body Mass Index
Brain-Derived Neurotrophic Factor - genetics
Case-Control Studies
Comorbidity
Diabetes
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - ethnology
Diabetes Mellitus, Type 2 - genetics
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinology
Endocrinopathies
Epidemiology
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Genetic Predisposition to Disease - ethnology
Genetic Predisposition to Disease - genetics
Genomes
Genotype
Geriatrics
Human Physiology
Humans
Internal Medicine
Japan
Male
Medical sciences
Medicine
Medicine & Public Health
Membrane Proteins - genetics
Membrane Transport Proteins - genetics
Metabolic Diseases
Metabolism
Middle Aged
Mitochondrial Membrane Transport Proteins
Mitochondrial Proteins - genetics
Obesity
Obesity - epidemiology
Obesity - ethnology
Obesity - genetics
Polymorphism, Single Nucleotide - genetics
Twins
University graduates
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Description
Summary:Aims/hypothesis In populations of East Asian descent, we performed a replication study of loci previously identified in populations of European descent as being associated with obesity measures such as BMI and type 2 diabetes. Methods We genotyped 14 single nucleotide polymorphisms (SNPs) from 13 candidate loci that had previously been identified by genome-wide association meta-analyses for obesity measures in Europeans. Genotyping was done in 18,264 participants from two general Japanese populations. For SNPs showing an obesity association in Japanese individuals, we further examined diabetes associations in up to 6,781 cases and 7,307 controls from a subset of the original, as well as from additional populations. Results Significant obesity associations ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-011-2086-8