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Ephrin/ephrin receptor expression during early stages of mouse inner ear development

Ephrins and their tyrosine kinase receptors (Ephs) are a highly conserved family of signaling proteins with various functions during embryonic development. Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modific...

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Published in:Developmental dynamics 2011-06, Vol.240 (6), p.1578-1585
Main Authors: Saeger, Bernhard M., Suhm, Martina, Neubüser, Annette
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creator Saeger, Bernhard M.
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description Ephrins and their tyrosine kinase receptors (Ephs) are a highly conserved family of signaling proteins with various functions during embryonic development. Among others, Eph/ephrin signaling is involved in regulating axon guidance, cell migration, and tissue border formation through inducing modifications of the actin cytoskeleton and cell adhesion. During development ephrins and Ephs are expressed in spatially and temporarily regulated patterns in a wide range of tissues. Here, we analyzed the expression of seven members of the Eph and four member of the ephrin family during early stages of mouse inner ear development by whole‐mount in situ hybridization. We detected expressions of EphA2, EphA4, EphA7, EphB1, ephrinA4, and ephrinA5 in and around the forming otic placode between embryonic day (E) 8.5 and E10, and report their detailed expression patterns. Our results reveal dynamic expression of several members of the ephrin/Eph family consistent with functions in otic placode development, invagination and neuroblast delamination. Developmental Dynamics 240:1578–1585, 2011. © 2011 Wiley‐Liss, Inc.
doi_str_mv 10.1002/dvdy.22632
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subjects Animals
Ear, Inner - embryology
Ear, Inner - metabolism
Ectoderm - embryology
Ectoderm - metabolism
embryo
ephrin
ephrin receptor
Ephrins - genetics
Ephrins - metabolism
expression
Gene Expression Regulation, Developmental
Mice
Models, Biological
mouse
Organogenesis - genetics
Organogenesis - physiology
otic placode
Receptor, EphB1 - genetics
Receptor, EphB1 - metabolism
Receptors, Eph Family - genetics
Receptors, Eph Family - metabolism
Somites - embryology
Somites - metabolism
Time Factors
title Ephrin/ephrin receptor expression during early stages of mouse inner ear development
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