Molecular Structure Influences the Stability of Membrane Penetrating Biointerfaces

Nanoscale patterning of hydrophobic bands on otherwise hydrophilic surfaces allows integration of inorganic structures through biological membranes, reminiscent of transmembrane proteins. Here we show that a set of innate molecular properties of the self-assembling hydrophobic band determine the res...

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Bibliographic Details
Published in:Nano letters 2011-05, Vol.11 (5), p.2066-2070
Main Authors: Almquist, Benjamin D, Melosh, Nicholas A
Format: Article
Language:English
Subjects:
Biocompatible Materials - chemistry
Biomimetics
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Exact sciences and technology
Lipid Bilayers - chemistry
Lipids - chemistry
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Materials science
Materials Testing
Membrane Lipids - chemistry
Membranes - metabolism
Methods of nanofabrication
Microscopy, Atomic Force - methods
Models, Statistical
Molecular Structure
Nanoscale pattern formation
Nanostructures - chemistry
Nanotechnology - methods
Physics
Protein Structure, Secondary
Self-assembly
Stress, Mechanical
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
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Summary:Nanoscale patterning of hydrophobic bands on otherwise hydrophilic surfaces allows integration of inorganic structures through biological membranes, reminiscent of transmembrane proteins. Here we show that a set of innate molecular properties of the self-assembling hydrophobic band determine the resulting interface stability. Surprisingly, hydrophobicity is found to be a secondary factor with monolayer crystallinity the major determinate of interface strength. These results begin to establish guidelines for seamless bioinorganic integration of nanoscale probes with lipid membranes.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl200542m