Early prediction and prevention of pre-eclampsia

Pre-eclampsia remains an important cause of maternal and perinatal mortality. The ability to predict the most severe forms of pre-eclampsia would allow closer surveillance and earlier intervention to improve outcomes. Although no definitive preventative treatment has been found to date, it is likely...

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Bibliographic Details
Published in:Best practice & research. Clinical obstetrics & gynaecology 2011-06, Vol.25 (3), p.343-354
Main Authors: Leslie, Karin, MRCOG, Thilaganathan, Basky, MD FRCOG, Papageorghiou, Aris, MD MRCOG
Format: Article
Language:English
Subjects:
Biomarkers
Blood Pressure
Early Diagnosis
Female
Humans
mean arterial pressure
Obstetrics and Gynecology
pre-eclampsia
Pre-Eclampsia - diagnosis
Pre-Eclampsia - prevention & control
Predictive Value of Tests
Pregnancy
screening
Ultrasonography, Doppler
uterine artery Doppler
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Summary:Pre-eclampsia remains an important cause of maternal and perinatal mortality. The ability to predict the most severe forms of pre-eclampsia would allow closer surveillance and earlier intervention to improve outcomes. Although no definitive preventative treatment has been found to date, it is likely that prospective treatments would need to start early in pregnancy to alter pathogenesis. Following recent advances in the understanding of the pathogenesis of this complex syndrome, new predictive tests are being evaluated. The most promising models incorporate biochemical and biophysical tests that combine assessments of placentation and maternal disease susceptibility.
ISSN:1521-6934
1532-1932
DOI:10.1016/j.bpobgyn.2011.01.002