When Parkinson’s disease patients go to sleep: specific sleep disturbances related to Parkinson’s disease

Nonmotor symptoms of Parkinson’s disease can be as disabling as the much better studied motor symptoms. Among the nonmotor manifestations are numerous forms of alterations of physiologic sleep patterns that may present at different stages during the course of disease. These include changes believed...

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Bibliographic Details
Published in:Journal of neurology 2011-05, Vol.258 (Suppl 2), p.328-335
Main Authors: Schulte, Eva C., Winkelmann, Juliane
Format: Article
Language:English
Subjects:
Brain - physiopathology
Humans
Medicine
Medicine & Public Health
Neurology
Neuroradiology
Neurosciences
Parkinson Disease - complications
Parkinson Disease - physiopathology
REM Sleep Behavior Disorder - etiology
REM Sleep Behavior Disorder - physiopathology
Sleep Wake Disorders - etiology
Sleep Wake Disorders - physiopathology
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Summary:Nonmotor symptoms of Parkinson’s disease can be as disabling as the much better studied motor symptoms. Among the nonmotor manifestations are numerous forms of alterations of physiologic sleep patterns that may present at different stages during the course of disease. These include changes believed to be primarily related to the underlying neurodegenerative process of the disease as well as those brought about secondarily, for example, by pharmacologic treatment. Also, sleep disturbances seen in Parkinson’s disease can range from temporarily increased daytime sleepiness after introduction of a dopamine agonist to the therapeutic regime to specific sleep-related diagnoses such as restless legs syndrome, rapid eye movement sleep behavior disorder, periodic limb movements in sleep, and sleep-related breathing disorders such as obstructive sleep apnea. In this review, we discuss the different specific sleep disturbances that arise in the context of Parkinson’s disease with a special emphasis on epidemiology, pathophysiology, and diagnosis.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-011-5933-0