Inflammation in epilepsy: Clinical observations

Summary Over the past decade, an increasing number of observations indicate that activation of inflammatory processes occurs in variety of focal epilepsies. Understanding the feature and consequences of neuroinflammation, including the contribution to development and perpetuation of seizures, as wel...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2011-05, Vol.52 (s3), p.26-32
Main Authors: Aronica, Eleonora, Crino, Peter B.
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Biomarkers - blood
Biomarkers - cerebrospinal fluid
Cerebrospinal fluid
Encephalitis - immunology
Encephalitis - pathology
Encephalitis - therapy
Epilepsy - immunology
Epilepsy - pathology
Epilepsy - therapy
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Hippocampal sclerosis
Humans
Imaging
Immune response
Immunomodulation - immunology
Malformations of cortical development
Malformations of Cortical Development - immunology
Malformations of Cortical Development - pathology
Malformations of Cortical Development - therapy
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Proinflammatory cytokines
Sclerosis - immunology
Sclerosis - pathology
Sclerosis - therapy
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Summary:Summary Over the past decade, an increasing number of observations indicate that activation of inflammatory processes occurs in variety of focal epilepsies. Understanding the feature and consequences of neuroinflammation, including the contribution to development and perpetuation of seizures, as well as to mood or cognitive dysfunction, is a major requisite for delineating its role in epilepsy. The present article discusses the most recent observations supporting the involvement of the inflammatory response in human focal epilepsy. It also evaluates emerging evidence concerning the possibility to identify epilepsy‐associated inflammatory biomarkers in cerebrospinal fluid and serum, as well as the potential application of neuroimaging approaches to study the inflammatory reactions in chronic epilepsy patients in vivo, aiming to improve the recognition of appropriate patient populations who might benefit from antiinflammatory or immunomodulatory therapies.
ISSN:0013-9580
1528-1167
DOI:10.1111/j.1528-1167.2011.03033.x