Ring-Opening Metathesis Polymerization-Based Synthesis of CaCO(3) Nanoparticle-Reinforced Polymeric Monoliths for Tissue Engineering

Porous monolithic materials have been prepared via ring-opening metathesis polymerization from norborn-2-ene and a 7-oxanorborn-2-ene-based cross-linker in the presence of porogenic solvents (i.e., 2-propanol and toluene) and norborn-2-enephosphonate surface-modified CaCO(3) nanoparticles, using the...

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Bibliographic Details
Published in:Macromolecular rapid communications. 2010-09, Vol.31 (17), p.1540-1545
Main Authors: Weichelt, Franziska, Frerich, Bernhard, Lenz, Solvig, Tiede, Stefanie, Buchmeiser, Michael R
Format: Article
Language:English
Online Access:Get full text
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Summary:Porous monolithic materials have been prepared via ring-opening metathesis polymerization from norborn-2-ene and a 7-oxanorborn-2-ene-based cross-linker in the presence of porogenic solvents (i.e., 2-propanol and toluene) and norborn-2-enephosphonate surface-modified CaCO(3) nanoparticles, using the 3(rd) -generation Grubbs-initiator RuCl(2) (Py)(2) (IMesH(2) )(CHPh). The experimental setup and the conditions chosen allowed for the manufacturing of polymeric monoliths characterized by a homogeneous distribution of the inorganic nanoparticles throughout the polymeric monolith. Depending on the nanoparticle content, the macropore diameters could be varied in the 30-120 µm regime. Noteworthy, the addition of nanoparticles did not affect the phase separation-triggered formation of the monolithic matrix nor the meso- and microporosity as evidenced by N(2) -adsorption experiments.
ISSN:1521-3927
DOI:10.1002/marc.201000317