Loading…
BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells
Purpose BMP-6, which belongs to the TGF-β superfamily, is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis. Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by...
Saved in:
| Published in: | Journal of cancer research and clinical oncology 2011-06, Vol.137 (6), p.985-995 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23 |
| container_end_page | 995 |
| container_issue | 6 |
| container_start_page | 985 |
| container_title | Journal of cancer research and clinical oncology |
| container_volume | 137 |
| creator | Wang, Chuan Hu, Fen Guo, Shaocong Mi, Dong Shen, Wenwen Zhang, Jie Qiao, Yuhuan Zhu, Tianhui Yang, Shuang |
| description | Purpose
BMP-6, which belongs to the TGF-β superfamily, is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis. Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by which BMP-6 exerts its anti-tumorigenic effect.
Methods
The Boyden chamber assay was used to examine the ability of BMP-6 and HO-1 in MCF-7 malignant progress. RT-PCR, western blot, luciferase assay, and quantitative CHIP were used to determine the potential mechanism and signaling pathways by which BMP-6 and HO-1 function as anti-metastatic factors in MCF-7 cells.
Results
The Boyden chamber assay showed that BMP-6 inhibited the migration and invasion of MCF-7 cells, which effect was significantly deprived by knockdown of HO-1. We further demonstrated that BMP-6 treatment resulted in an activation of HO-1 transcription through the recruitment of Smad1/5 to the Smad-responsive element on its promoter. In addition, BMP-6-induced up-regulation of HO-1 exhibited an inhibitory effect on MMP-9 secretion in a paracrine action in MCF-7 cells. Overexpression of BMP-6 and HO-1 synergistically suppressed MMP-9 transcription, which effect was specifically mediated via the MAPK/p38/AP-1 signaling. However, blockade of HO-1 using ZnPPIX totally abolished BMP-6-regulated MMP-9 activation in MCF-7 cells.
Conclusions
These observations suggest a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment. |
| doi_str_mv | 10.1007/s00432-010-0963-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_866536212</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>866536212</sourcerecordid><originalsourceid>FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23</originalsourceid><addsrcrecordid>eNp1kE1r3DAQhkVpSDYfP6CXIgolJzUaaS1Lx2ZpkkKW5JCeehCyPd44eO2txoZsfn1kdtNAoScxo2dGrx7GPoH8BlLmFyTlXCshQQrpjBYvH9gMpg5onX1kMwk5iEyBOWLHRE8y1VmuDtmRAtBG5XrGfl8u74XhTffYFM1AfJlKx_F5E5Go6TtebHnE1diGoelW_BHXyPvn7Qq7QCggDfLl4krkvIgYaOBl6EqMvMS2pVN2UIeW8Gx_nrBfVz8eFjfi9u765-L7rSjnxgyiMirYOkd0wVoZlLaZqfPCzq0DVztZl6nrQope1ZV1WppKW2NCgZUOqlL6hJ3v9m5i_2dEGvy6oSlB6LAfySc4S9-FifzyD_nUj7FL4SZIZQbsBMEOKmNPFLH2m9isQ9x6kH7y7nfeffLuJ-_-Jc183i8eizVWfyfeRCfg6x4IVIa2jslTQ-_cHJzJwSVO7ThKV90K43vC_7_-CsFnmGI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>866256182</pqid></control><display><type>article</type><title>BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells</title><source>Springer Nature</source><creator>Wang, Chuan ; Hu, Fen ; Guo, Shaocong ; Mi, Dong ; Shen, Wenwen ; Zhang, Jie ; Qiao, Yuhuan ; Zhu, Tianhui ; Yang, Shuang</creator><creatorcontrib>Wang, Chuan ; Hu, Fen ; Guo, Shaocong ; Mi, Dong ; Shen, Wenwen ; Zhang, Jie ; Qiao, Yuhuan ; Zhu, Tianhui ; Yang, Shuang</creatorcontrib><description>Purpose
BMP-6, which belongs to the TGF-β superfamily, is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis. Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by which BMP-6 exerts its anti-tumorigenic effect.
Methods
The Boyden chamber assay was used to examine the ability of BMP-6 and HO-1 in MCF-7 malignant progress. RT-PCR, western blot, luciferase assay, and quantitative CHIP were used to determine the potential mechanism and signaling pathways by which BMP-6 and HO-1 function as anti-metastatic factors in MCF-7 cells.
Results
The Boyden chamber assay showed that BMP-6 inhibited the migration and invasion of MCF-7 cells, which effect was significantly deprived by knockdown of HO-1. We further demonstrated that BMP-6 treatment resulted in an activation of HO-1 transcription through the recruitment of Smad1/5 to the Smad-responsive element on its promoter. In addition, BMP-6-induced up-regulation of HO-1 exhibited an inhibitory effect on MMP-9 secretion in a paracrine action in MCF-7 cells. Overexpression of BMP-6 and HO-1 synergistically suppressed MMP-9 transcription, which effect was specifically mediated via the MAPK/p38/AP-1 signaling. However, blockade of HO-1 using ZnPPIX totally abolished BMP-6-regulated MMP-9 activation in MCF-7 cells.
Conclusions
These observations suggest a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment.</description><identifier>ISSN: 0171-5216</identifier><identifier>EISSN: 1432-1335</identifier><identifier>DOI: 10.1007/s00432-010-0963-z</identifier><identifier>PMID: 21136273</identifier><identifier>CODEN: JCROD7</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer-Verlag</publisher><subject>Antineoplastic agents ; Biological and medical sciences ; Bone Morphogenetic Protein 6 - physiology ; Breast cancer ; Breast Neoplasms - pathology ; Cancer Research ; Cell Line, Tumor ; Female ; Gynecology. Andrology. Obstetrics ; Hematology ; Heme Oxygenase-1 - genetics ; Heme Oxygenase-1 - physiology ; Humans ; Internal Medicine ; Mammary gland diseases ; Matrix Metalloproteinase 9 - genetics ; Matrix Metalloproteinase Inhibitors ; Medical sciences ; Medicine ; Medicine & Public Health ; Metastasis ; Neoplasm Metastasis - prevention & control ; Oncology ; Original Paper ; p38 Mitogen-Activated Protein Kinases - physiology ; Pharmacology. Drug treatments ; Proteins ; Signal Transduction ; Smad Proteins - physiology ; Transcription Factor AP-1 - physiology ; Tumors</subject><ispartof>Journal of cancer research and clinical oncology, 2011-06, Vol.137 (6), p.985-995</ispartof><rights>Springer-Verlag 2010</rights><rights>2015 INIST-CNRS</rights><rights>Springer-Verlag 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23</citedby><cites>FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24196719$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21136273$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Chuan</creatorcontrib><creatorcontrib>Hu, Fen</creatorcontrib><creatorcontrib>Guo, Shaocong</creatorcontrib><creatorcontrib>Mi, Dong</creatorcontrib><creatorcontrib>Shen, Wenwen</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Qiao, Yuhuan</creatorcontrib><creatorcontrib>Zhu, Tianhui</creatorcontrib><creatorcontrib>Yang, Shuang</creatorcontrib><title>BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells</title><title>Journal of cancer research and clinical oncology</title><addtitle>J Cancer Res Clin Oncol</addtitle><addtitle>J Cancer Res Clin Oncol</addtitle><description>Purpose
BMP-6, which belongs to the TGF-β superfamily, is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis. Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by which BMP-6 exerts its anti-tumorigenic effect.
Methods
The Boyden chamber assay was used to examine the ability of BMP-6 and HO-1 in MCF-7 malignant progress. RT-PCR, western blot, luciferase assay, and quantitative CHIP were used to determine the potential mechanism and signaling pathways by which BMP-6 and HO-1 function as anti-metastatic factors in MCF-7 cells.
Results
The Boyden chamber assay showed that BMP-6 inhibited the migration and invasion of MCF-7 cells, which effect was significantly deprived by knockdown of HO-1. We further demonstrated that BMP-6 treatment resulted in an activation of HO-1 transcription through the recruitment of Smad1/5 to the Smad-responsive element on its promoter. In addition, BMP-6-induced up-regulation of HO-1 exhibited an inhibitory effect on MMP-9 secretion in a paracrine action in MCF-7 cells. Overexpression of BMP-6 and HO-1 synergistically suppressed MMP-9 transcription, which effect was specifically mediated via the MAPK/p38/AP-1 signaling. However, blockade of HO-1 using ZnPPIX totally abolished BMP-6-regulated MMP-9 activation in MCF-7 cells.
Conclusions
These observations suggest a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment.</description><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Bone Morphogenetic Protein 6 - physiology</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - pathology</subject><subject>Cancer Research</subject><subject>Cell Line, Tumor</subject><subject>Female</subject><subject>Gynecology. Andrology. Obstetrics</subject><subject>Hematology</subject><subject>Heme Oxygenase-1 - genetics</subject><subject>Heme Oxygenase-1 - physiology</subject><subject>Humans</subject><subject>Internal Medicine</subject><subject>Mammary gland diseases</subject><subject>Matrix Metalloproteinase 9 - genetics</subject><subject>Matrix Metalloproteinase Inhibitors</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metastasis</subject><subject>Neoplasm Metastasis - prevention & control</subject><subject>Oncology</subject><subject>Original Paper</subject><subject>p38 Mitogen-Activated Protein Kinases - physiology</subject><subject>Pharmacology. Drug treatments</subject><subject>Proteins</subject><subject>Signal Transduction</subject><subject>Smad Proteins - physiology</subject><subject>Transcription Factor AP-1 - physiology</subject><subject>Tumors</subject><issn>0171-5216</issn><issn>1432-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNp1kE1r3DAQhkVpSDYfP6CXIgolJzUaaS1Lx2ZpkkKW5JCeehCyPd44eO2txoZsfn1kdtNAoScxo2dGrx7GPoH8BlLmFyTlXCshQQrpjBYvH9gMpg5onX1kMwk5iEyBOWLHRE8y1VmuDtmRAtBG5XrGfl8u74XhTffYFM1AfJlKx_F5E5Go6TtebHnE1diGoelW_BHXyPvn7Qq7QCggDfLl4krkvIgYaOBl6EqMvMS2pVN2UIeW8Gx_nrBfVz8eFjfi9u765-L7rSjnxgyiMirYOkd0wVoZlLaZqfPCzq0DVztZl6nrQope1ZV1WppKW2NCgZUOqlL6hJ3v9m5i_2dEGvy6oSlB6LAfySc4S9-FifzyD_nUj7FL4SZIZQbsBMEOKmNPFLH2m9isQ9x6kH7y7nfeffLuJ-_-Jc183i8eizVWfyfeRCfg6x4IVIa2jslTQ-_cHJzJwSVO7ThKV90K43vC_7_-CsFnmGI</recordid><startdate>20110601</startdate><enddate>20110601</enddate><creator>Wang, Chuan</creator><creator>Hu, Fen</creator><creator>Guo, Shaocong</creator><creator>Mi, Dong</creator><creator>Shen, Wenwen</creator><creator>Zhang, Jie</creator><creator>Qiao, Yuhuan</creator><creator>Zhu, Tianhui</creator><creator>Yang, Shuang</creator><general>Springer-Verlag</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20110601</creationdate><title>BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells</title><author>Wang, Chuan ; Hu, Fen ; Guo, Shaocong ; Mi, Dong ; Shen, Wenwen ; Zhang, Jie ; Qiao, Yuhuan ; Zhu, Tianhui ; Yang, Shuang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Antineoplastic agents</topic><topic>Biological and medical sciences</topic><topic>Bone Morphogenetic Protein 6 - physiology</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - pathology</topic><topic>Cancer Research</topic><topic>Cell Line, Tumor</topic><topic>Female</topic><topic>Gynecology. Andrology. Obstetrics</topic><topic>Hematology</topic><topic>Heme Oxygenase-1 - genetics</topic><topic>Heme Oxygenase-1 - physiology</topic><topic>Humans</topic><topic>Internal Medicine</topic><topic>Mammary gland diseases</topic><topic>Matrix Metalloproteinase 9 - genetics</topic><topic>Matrix Metalloproteinase Inhibitors</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metastasis</topic><topic>Neoplasm Metastasis - prevention & control</topic><topic>Oncology</topic><topic>Original Paper</topic><topic>p38 Mitogen-Activated Protein Kinases - physiology</topic><topic>Pharmacology. Drug treatments</topic><topic>Proteins</topic><topic>Signal Transduction</topic><topic>Smad Proteins - physiology</topic><topic>Transcription Factor AP-1 - physiology</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Chuan</creatorcontrib><creatorcontrib>Hu, Fen</creatorcontrib><creatorcontrib>Guo, Shaocong</creatorcontrib><creatorcontrib>Mi, Dong</creatorcontrib><creatorcontrib>Shen, Wenwen</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Qiao, Yuhuan</creatorcontrib><creatorcontrib>Zhu, Tianhui</creatorcontrib><creatorcontrib>Yang, Shuang</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection (Proquest)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database (Proquest)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cancer research and clinical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Chuan</au><au>Hu, Fen</au><au>Guo, Shaocong</au><au>Mi, Dong</au><au>Shen, Wenwen</au><au>Zhang, Jie</au><au>Qiao, Yuhuan</au><au>Zhu, Tianhui</au><au>Yang, Shuang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells</atitle><jtitle>Journal of cancer research and clinical oncology</jtitle><stitle>J Cancer Res Clin Oncol</stitle><addtitle>J Cancer Res Clin Oncol</addtitle><date>2011-06-01</date><risdate>2011</risdate><volume>137</volume><issue>6</issue><spage>985</spage><epage>995</epage><pages>985-995</pages><issn>0171-5216</issn><eissn>1432-1335</eissn><coden>JCROD7</coden><abstract>Purpose
BMP-6, which belongs to the TGF-β superfamily, is a multifunctional molecule with distinct abilities in embryogenesis and organogenesis. Our recent research has implied that BMP-6 may suppress breast cancer metastasis. In the present study, we extended to elucidate the molecular mechanism by which BMP-6 exerts its anti-tumorigenic effect.
Methods
The Boyden chamber assay was used to examine the ability of BMP-6 and HO-1 in MCF-7 malignant progress. RT-PCR, western blot, luciferase assay, and quantitative CHIP were used to determine the potential mechanism and signaling pathways by which BMP-6 and HO-1 function as anti-metastatic factors in MCF-7 cells.
Results
The Boyden chamber assay showed that BMP-6 inhibited the migration and invasion of MCF-7 cells, which effect was significantly deprived by knockdown of HO-1. We further demonstrated that BMP-6 treatment resulted in an activation of HO-1 transcription through the recruitment of Smad1/5 to the Smad-responsive element on its promoter. In addition, BMP-6-induced up-regulation of HO-1 exhibited an inhibitory effect on MMP-9 secretion in a paracrine action in MCF-7 cells. Overexpression of BMP-6 and HO-1 synergistically suppressed MMP-9 transcription, which effect was specifically mediated via the MAPK/p38/AP-1 signaling. However, blockade of HO-1 using ZnPPIX totally abolished BMP-6-regulated MMP-9 activation in MCF-7 cells.
Conclusions
These observations suggest a novel role of BMP-6/HO-1 cascade to relieve breast cancer metastasis by regulating the secretion of growth factors in tumor microenvironment.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer-Verlag</pub><pmid>21136273</pmid><doi>10.1007/s00432-010-0963-z</doi><tpages>11</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0171-5216 |
| ispartof | Journal of cancer research and clinical oncology, 2011-06, Vol.137 (6), p.985-995 |
| issn | 0171-5216 1432-1335 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_866536212 |
| source | Springer Nature |
| subjects | Antineoplastic agents Biological and medical sciences Bone Morphogenetic Protein 6 - physiology Breast cancer Breast Neoplasms - pathology Cancer Research Cell Line, Tumor Female Gynecology. Andrology. Obstetrics Hematology Heme Oxygenase-1 - genetics Heme Oxygenase-1 - physiology Humans Internal Medicine Mammary gland diseases Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase Inhibitors Medical sciences Medicine Medicine & Public Health Metastasis Neoplasm Metastasis - prevention & control Oncology Original Paper p38 Mitogen-Activated Protein Kinases - physiology Pharmacology. Drug treatments Proteins Signal Transduction Smad Proteins - physiology Transcription Factor AP-1 - physiology Tumors |
| title | BMP-6 inhibits MMP-9 expression by regulating heme oxygenase-1 in MCF-7 breast cancer cells |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T21%3A10%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=BMP-6%20inhibits%20MMP-9%20expression%20by%20regulating%20heme%20oxygenase-1%20in%20MCF-7%20breast%20cancer%20cells&rft.jtitle=Journal%20of%20cancer%20research%20and%20clinical%20oncology&rft.au=Wang,%20Chuan&rft.date=2011-06-01&rft.volume=137&rft.issue=6&rft.spage=985&rft.epage=995&rft.pages=985-995&rft.issn=0171-5216&rft.eissn=1432-1335&rft.coden=JCROD7&rft_id=info:doi/10.1007/s00432-010-0963-z&rft_dat=%3Cproquest_cross%3E866536212%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c466t-d62a8f7ee9a880a23856f7b848919f90fc80a9a757dfd89306d3866abed3a2d23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=866256182&rft_id=info:pmid/21136273&rfr_iscdi=true |