Evaluation of spectral entropy to measure anaesthetic depth and antinociception in sevoflurane-anaesthetised Beagle dogs

The use of spectral entropy to determine anaesthetic depth and antinociception was evaluated in sevoflurane-anaesthetised Beagle dogs. Dogs were anaesthetised at each of five multiples of their individual minimum alveolar concentrations (MAC; 0.75, 1, 1.25, 1.5 and 1.75MAC), and response entropy (RE...

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Published in:The veterinary journal (1997) 2011-06, Vol.188 (3), p.352-355
Main Authors: Morgaz, Juan, Granados, María del Mar, Domínguez, Juan Manuel, Navarrete, Rocío, Fernández, Andrés, Galán, Alba, Muñoz, Pilar, Gómez-Villamandos, Rafael J.
Format: Article
Language:English
Subjects:
Analgesia
anesthesia
Anesthesia - veterinary
Anesthetics, Inhalation - pharmacology
Animals
Beagle
Dog
Dogs
Entropy
Female
Male
Methyl Ethers - pharmacology
Monitoring, Intraoperative - methods
Monitoring, Intraoperative - veterinary
Pain Measurement - methods
Pain Measurement - veterinary
Pulmonary Alveoli - metabolism
Response entropy
Sevoflurane
spectral analysis
State entropy
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Summary:The use of spectral entropy to determine anaesthetic depth and antinociception was evaluated in sevoflurane-anaesthetised Beagle dogs. Dogs were anaesthetised at each of five multiples of their individual minimum alveolar concentrations (MAC; 0.75, 1, 1.25, 1.5 and 1.75MAC), and response entropy (RE), state entropy (SE), RE–SE difference, burst suppression rate (BSR) and cardiorespiratory parameters were recorded before and after a painful stimulus. RE, SE and RE–SE difference did not change significantly after the stimuli. The correlation between MAC–entropy parameters was weak, but these values increased when 1.75MAC results were excluded from the analysis. BSR was different to zero at 1.5 and 1.75MAC. It was concluded that RE and RE–SE differences were not adequate indicators of antinociception and SE and RE were unable to detect deep planes of anaesthesia in dogs, although they both distinguished the awake and unconscious states.
ISSN:1090-0233
1532-2971
DOI:10.1016/j.tvjl.2010.06.001