Adherence to Statins, Subsequent Healthcare Costs, and Cardiovascular Hospitalizations

Statins are the primary agents used to decrease low-density lipoprotein cholesterol. Although adherence to statins improves the clinical outcomes, the affect of statin adherence on healthcare costs has not been well studied. To examine the relation among statin adherence, subsequent hospitalizations...

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Bibliographic Details
Published in:The American journal of cardiology 2011-06, Vol.107 (11), p.1662-1666
Main Authors: Pittman, Donald G., PharmD, Chen, William, PhD, Bowlin, Steven J., DO, PhD, Foody, JoAnne M., MD
Format: Article
Language:English
Subjects:
Adolescent
Adult
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiovascular
Cardiovascular disease
Female
Health Care Costs
Health care expenditures
Hospitalization
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - economics
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Low density lipoprotein
Male
Medical sciences
Medication Adherence
Middle Aged
Retrospective Studies
Statins
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Summary:Statins are the primary agents used to decrease low-density lipoprotein cholesterol. Although adherence to statins improves the clinical outcomes, the affect of statin adherence on healthcare costs has not been well studied. To examine the relation among statin adherence, subsequent hospitalizations, and healthcare costs, we conducted a retrospective cohort study of 381,422 patients, aged 18 to 61 years, using an integrated pharmacy and medical claims database. We measured adherence using the medication possession ratio (MPR) for 12 months and the healthcare costs and cardiovascular disease-related hospitalizations during the subsequent 18 months. Of those studied, 258,013 (67.6%) were adherent (MPR ≥80%), 65,795 (17.3%) had an MPR of 60% to 79%, and 57,614 (15.1%) had an MPR of
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2011.01.052