Study of influence of prodigiozan-dependent comuton on slow efflux of calcium ions from the matrix of mitochondria of various tissue and species origins

Earlier, Elbakidze et al showed that activation of Kupffer cells (KCs) in the liver by injecting the endotoxin prodigiozan into the bloodstream of the rat leads to accumulation in it of comuton, a low molecular weight regulator of mitochondrial processes. They found that the prodigiozan dependent co...

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Published in:Doklady. Biochemistry and biophysics 2011-04, Vol.437 (1), p.109-112
Main Authors: Elbakidze, G. M., Elbakidze, A. G., Medentsev, A. G.
Format: Article
Language:English
Subjects:
Animals
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Biophysics and Molecular Biology
Calcium
Calcium - metabolism
Calcium Channels - drug effects
Calcium Channels - metabolism
Cations, Divalent - metabolism
Ions
Kidney - metabolism
Life Sciences
Liver - metabolism
Lung - metabolism
Mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Molecular weight
Prodigiozan - pharmacology
Rats
Ruthenium Red - pharmacology
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Summary:Earlier, Elbakidze et al showed that activation of Kupffer cells (KCs) in the liver by injecting the endotoxin prodigiozan into the bloodstream of the rat leads to accumulation in it of comuton, a low molecular weight regulator of mitochondrial processes. They found that the prodigiozan dependent comuton (PDC) can stimulate Ca2+ efflux from mitochondria of hepatocytes. To explain the physiological function of PDC, it was necessary to establish whether it was able to regulate Ca2+ efflux from the mitochondrial matrix.
ISSN:1607-6729
1608-3091
DOI:10.1134/S160767291102013X