Effects of low-energy NMR on posttraumatic osteoarthritis: observations in a rabbit model

Objective To evaluate a possible beneficial effect of low-energy nuclear magnetic resonance (NMR) on cartilage in moderate and severe posttraumatic osteoarthrosis in the rabbit using a macroscopic and a histological grading system. Design Following transection of the anterior cruciate ligament of bo...

Full description

Saved in:
Bibliographic Details
Published in:Archives of orthopaedic and trauma surgery 2011-06, Vol.131 (6), p.863-868
Main Authors: Jansen, Hendrik, Frey, Sönke P., Paletta, Jürgen, Meffert, Rainer H.
Format: Article
Language:English
Subjects:
Animals
Knee
Knee Arthroplasty
Magnetic Resonance Spectroscopy
Male
Medicine
Medicine & Public Health
NMR
Nuclear magnetic resonance
Orthopedics
Osteoarthritis, Knee - pathology
Osteoarthritis, Knee - therapy
Rabbits
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective To evaluate a possible beneficial effect of low-energy nuclear magnetic resonance (NMR) on cartilage in moderate and severe posttraumatic osteoarthrosis in the rabbit using a macroscopic and a histological grading system. Design Following transection of the anterior cruciate ligament of both knees in 24 skeletally mature New Zealand White rabbits, we observed different stages of osteoarthrosis (OA) 6 and 12 weeks postoperatively. Animals were randomized into four groups: Group 1 (eight animals) was treated after 6 weeks by NMR (magnetic field: 20–40 G, interference field: 2.35 mT, 100 kHz; MBST ® Device, MedTec, Germany), with 1 h of treatment for seven consecutive days. Group 2 was treated in the same pattern after 12 weeks. The sham-operated groups 3 and 4 received no treatment. Seven days after the last treatment, OA was macroscopically graded and hyaline cartilage of the load bearing area was evaluated histologically according to the Mankin scale. Results Macroscopically, there was less OA in group 1 ( p  
ISSN:0936-8051
1434-3916
DOI:10.1007/s00402-010-1205-1