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Reproductive and developmental toxicities of zinc supplemented rats
Reproductive and developmental toxicities of zinc supplementation in F 0 rats and F 1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl 2) at 0.0, 7.5, 15 and 30 mg/kg-d. ZnCl 2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter,...
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| Published in: | Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-02, Vol.31 (2), p.134-143 |
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| container_end_page | 143 |
| container_issue | 2 |
| container_start_page | 134 |
| container_title | Reproductive toxicology (Elmsford, N.Y.) |
| container_volume | 31 |
| creator | Johnson, F.O. Gilbreath, E.T. Ogden, L. Graham, T.C. Gorham, S. |
| description | Reproductive and developmental toxicities of zinc supplementation in F
0 rats and F
1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl
2) at 0.0, 7.5, 15 and 30
mg/kg-d. ZnCl
2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F
0 females, ZnCl
2 was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F
0 males, ZnCl
2 significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F
1 males exhibited, a significant (
p
<
0.05) increase in anogenital distance, whereas ZnCl
2 hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl
2 supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring. |
| doi_str_mv | 10.1016/j.reprotox.2010.10.009 |
| format | article |
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0 rats and F
1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl
2) at 0.0, 7.5, 15 and 30
mg/kg-d. ZnCl
2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F
0 females, ZnCl
2 was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F
0 males, ZnCl
2 significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F
1 males exhibited, a significant (
p
<
0.05) increase in anogenital distance, whereas ZnCl
2 hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl
2 supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.</description><identifier>ISSN: 0890-6238</identifier><identifier>EISSN: 1873-1708</identifier><identifier>DOI: 10.1016/j.reprotox.2010.10.009</identifier><identifier>PMID: 20977935</identifier><language>eng</language><publisher>Amsterdam: Elsevier Inc</publisher><subject>Animals ; Biological and medical sciences ; Body Weight - drug effects ; Chemical and industrial products toxicology. Toxic occupational diseases ; Chlorides - administration & dosage ; Chlorides - toxicity ; Dietary Supplements - toxicity ; Embryology: invertebrates and vertebrates. Teratology ; Embryonic Development - drug effects ; Energy Metabolism - drug effects ; Female ; Fetal Death - chemically induced ; Fetal Resorption - chemically induced ; Fundamental and applied biological sciences. Psychology ; Hepatotoxicity ; Hydronephrosis ; Kidney ; Kidneys ; Lactation ; Litter Size - drug effects ; Liver ; Liver - embryology ; Male ; Medical sciences ; Metals and various inorganic compounds ; Nephrology. Urinary tract diseases ; Neprotoxicity ; Organ Size - drug effects ; Pregnancy ; Rats ; Rats, Sprague-Dawley ; Reproduction ; Reproduction - drug effects ; Risk Factors ; Sex Factors ; Teratology. Teratogens ; Toxicity ; Toxicology ; Urinary system involvement in other diseases. Miscellaneous ; Urinary tract. Prostate gland ; Zinc ; Zinc Compounds - administration & dosage ; Zinc Compounds - toxicity</subject><ispartof>Reproductive toxicology (Elmsford, N.Y.), 2011-02, Vol.31 (2), p.134-143</ispartof><rights>2010 Elsevier Inc.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c429t-882ea0286a1cc9f52a62cf2cd711836d14c7ed5356c2d880345c9cb22480a4d23</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24037399$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20977935$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Johnson, F.O.</creatorcontrib><creatorcontrib>Gilbreath, E.T.</creatorcontrib><creatorcontrib>Ogden, L.</creatorcontrib><creatorcontrib>Graham, T.C.</creatorcontrib><creatorcontrib>Gorham, S.</creatorcontrib><title>Reproductive and developmental toxicities of zinc supplemented rats</title><title>Reproductive toxicology (Elmsford, N.Y.)</title><addtitle>Reprod Toxicol</addtitle><description>Reproductive and developmental toxicities of zinc supplementation in F
0 rats and F
1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl
2) at 0.0, 7.5, 15 and 30
mg/kg-d. ZnCl
2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F
0 females, ZnCl
2 was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F
0 males, ZnCl
2 significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F
1 males exhibited, a significant (
p
<
0.05) increase in anogenital distance, whereas ZnCl
2 hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl
2 supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.</description><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Chemical and industrial products toxicology. Toxic occupational diseases</subject><subject>Chlorides - administration & dosage</subject><subject>Chlorides - toxicity</subject><subject>Dietary Supplements - toxicity</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>Embryonic Development - drug effects</subject><subject>Energy Metabolism - drug effects</subject><subject>Female</subject><subject>Fetal Death - chemically induced</subject><subject>Fetal Resorption - chemically induced</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hepatotoxicity</subject><subject>Hydronephrosis</subject><subject>Kidney</subject><subject>Kidneys</subject><subject>Lactation</subject><subject>Litter Size - drug effects</subject><subject>Liver</subject><subject>Liver - embryology</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metals and various inorganic compounds</subject><subject>Nephrology. Urinary tract diseases</subject><subject>Neprotoxicity</subject><subject>Organ Size - drug effects</subject><subject>Pregnancy</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Reproduction</subject><subject>Reproduction - drug effects</subject><subject>Risk Factors</subject><subject>Sex Factors</subject><subject>Teratology. Teratogens</subject><subject>Toxicity</subject><subject>Toxicology</subject><subject>Urinary system involvement in other diseases. Miscellaneous</subject><subject>Urinary tract. Prostate gland</subject><subject>Zinc</subject><subject>Zinc Compounds - administration & dosage</subject><subject>Zinc Compounds - toxicity</subject><issn>0890-6238</issn><issn>1873-1708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><recordid>eNqFkE1r3DAQhkVpabZJ_0LwpfTk7Uiy9XFLWZK0ECiE5iyU0Ri0eG1Hspekvz52d5MccxqYeead4WHsnMOaA1c_tutEQ-rH_nEt4H9zDWA_sBU3WpZcg_nIVmAslEpIc8K-5LwFgEpb_ZmdCLBaW1mv2OZ2iQkTjnFPhe9CEWhPbT_sqBt9W8wHIsYxUi76pvgXOyzyNAwtLXMKRfJjPmOfGt9m-nqsp-zu6vLv5ld58-f69-bnTYmVsGNpjCAPwijPEW1TC68ENgKD5txIFXiFmkIta4UiGAOyqtHivRCVAV8FIU_Z90Pu_PHDRHl0u5iR2tZ31E_ZGaW1lLON98m6tqC4MDOpDiSmPudEjRtS3Pn05Di4xbTbuhfTbjG99GfT8-L58cR0v6Pwuvaidga-HQGf0bdN8h3G_MZVILW0S9DFgaNZ3T5SchkjdUghJsLRhT6-98sz-36gEA</recordid><startdate>20110201</startdate><enddate>20110201</enddate><creator>Johnson, F.O.</creator><creator>Gilbreath, E.T.</creator><creator>Ogden, L.</creator><creator>Graham, T.C.</creator><creator>Gorham, S.</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7ST</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>7U7</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20110201</creationdate><title>Reproductive and developmental toxicities of zinc supplemented rats</title><author>Johnson, F.O. ; Gilbreath, E.T. ; Ogden, L. ; Graham, T.C. ; Gorham, S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c429t-882ea0286a1cc9f52a62cf2cd711836d14c7ed5356c2d880345c9cb22480a4d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Chemical and industrial products toxicology. Toxic occupational diseases</topic><topic>Chlorides - administration & dosage</topic><topic>Chlorides - toxicity</topic><topic>Dietary Supplements - toxicity</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>Embryonic Development - drug effects</topic><topic>Energy Metabolism - drug effects</topic><topic>Female</topic><topic>Fetal Death - chemically induced</topic><topic>Fetal Resorption - chemically induced</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hepatotoxicity</topic><topic>Hydronephrosis</topic><topic>Kidney</topic><topic>Kidneys</topic><topic>Lactation</topic><topic>Litter Size - drug effects</topic><topic>Liver</topic><topic>Liver - embryology</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metals and various inorganic compounds</topic><topic>Nephrology. Urinary tract diseases</topic><topic>Neprotoxicity</topic><topic>Organ Size - drug effects</topic><topic>Pregnancy</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Reproduction</topic><topic>Reproduction - drug effects</topic><topic>Risk Factors</topic><topic>Sex Factors</topic><topic>Teratology. Teratogens</topic><topic>Toxicity</topic><topic>Toxicology</topic><topic>Urinary system involvement in other diseases. Miscellaneous</topic><topic>Urinary tract. Prostate gland</topic><topic>Zinc</topic><topic>Zinc Compounds - administration & dosage</topic><topic>Zinc Compounds - toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Johnson, F.O.</creatorcontrib><creatorcontrib>Gilbreath, E.T.</creatorcontrib><creatorcontrib>Ogden, L.</creatorcontrib><creatorcontrib>Graham, T.C.</creatorcontrib><creatorcontrib>Gorham, S.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Risk Abstracts</collection><collection>Safety Science and Risk</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Johnson, F.O.</au><au>Gilbreath, E.T.</au><au>Ogden, L.</au><au>Graham, T.C.</au><au>Gorham, S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reproductive and developmental toxicities of zinc supplemented rats</atitle><jtitle>Reproductive toxicology (Elmsford, N.Y.)</jtitle><addtitle>Reprod Toxicol</addtitle><date>2011-02-01</date><risdate>2011</risdate><volume>31</volume><issue>2</issue><spage>134</spage><epage>143</epage><pages>134-143</pages><issn>0890-6238</issn><eissn>1873-1708</eissn><abstract>Reproductive and developmental toxicities of zinc supplementation in F
0 rats and F
1 progeny were examined. Rats were treated by gavaging with zinc chloride (ZnCl
2) at 0.0, 7.5, 15 and 30
mg/kg-d. ZnCl
2 treatment was associated with deficient energy imbalances, reduced number of live pups/litter, decreased live birth index, increased mortality and increased fetal resorption. Changes in serum clinical chemistry and hematologic parameters were sex-related. In F
0 females, ZnCl
2 was associated with increased liver/body weight ratios, reduced creatinine and reduced alkaline phosphatase concentrations. In F
0 males, ZnCl
2 significantly increased relative liver weight and elevated γ-GGT. In addition, at birth, F
1 males exhibited, a significant (
p
<
0.05) increase in anogenital distance, whereas ZnCl
2 hastened the time of eye opening and incisor eruption in males and females. These results indicate that excess ZnCl
2 supplementation before and during pregnancy and during lactation could pose some health risk concerns to pregnant mothers and their offspring.</abstract><cop>Amsterdam</cop><pub>Elsevier Inc</pub><pmid>20977935</pmid><doi>10.1016/j.reprotox.2010.10.009</doi><tpages>10</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0890-6238 |
| ispartof | Reproductive toxicology (Elmsford, N.Y.), 2011-02, Vol.31 (2), p.134-143 |
| issn | 0890-6238 1873-1708 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_867733010 |
| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Animals Biological and medical sciences Body Weight - drug effects Chemical and industrial products toxicology. Toxic occupational diseases Chlorides - administration & dosage Chlorides - toxicity Dietary Supplements - toxicity Embryology: invertebrates and vertebrates. Teratology Embryonic Development - drug effects Energy Metabolism - drug effects Female Fetal Death - chemically induced Fetal Resorption - chemically induced Fundamental and applied biological sciences. Psychology Hepatotoxicity Hydronephrosis Kidney Kidneys Lactation Litter Size - drug effects Liver Liver - embryology Male Medical sciences Metals and various inorganic compounds Nephrology. Urinary tract diseases Neprotoxicity Organ Size - drug effects Pregnancy Rats Rats, Sprague-Dawley Reproduction Reproduction - drug effects Risk Factors Sex Factors Teratology. Teratogens Toxicity Toxicology Urinary system involvement in other diseases. Miscellaneous Urinary tract. Prostate gland Zinc Zinc Compounds - administration & dosage Zinc Compounds - toxicity |
| title | Reproductive and developmental toxicities of zinc supplemented rats |
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