Administration of bisphenol A to dams during perinatal period modifies molecular and morphological reproductive parameters of the offspring

• Published in: Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2011-02, Vol.31 (2), p.177-183
• Main Authors: Mendoza-Rodríguez, C. Adriana, García-Guzmán, Montserrat, Baranda-Avila, Noemí, Morimoto, Sumiko, Perrot-Applanat, Martine, Cerbón, Marco
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis; Apoptosis - drug effects; Benzhydryl Compounds; Biological and medical sciences; Bisphenol-A; Development; Embryology: invertebrates and vertebrates. Teratology; Endocrine disruptor; Epithelium - anatomy & histology; Epithelium - chemistry; Epithelium - drug effects; Estrogen Receptor alpha - analysis; Estrogen receptor-α; Estrogens, Non-Steroidal - administration & dosage; Estrogens, Non-Steroidal - toxicity; Estrous Cycle - drug effects; Female; Fundamental and applied biological sciences. Psychology; Lactation; Medical sciences; Phenols - administration & dosage; Phenols - toxicity; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Reproduction - drug effects; Reproduction - physiology; Teratology. Teratogens; Toxicology; Uterus; Uterus - anatomy & histology; Uterus - chemistry; Uterus - drug effects; Water
• ISSN: 0890-6238; 1873-1708
• DOI: 10.1016/j.reprotox.2010.10.013

▶ BPA administered to dams induce irregular estrous cycle of the offspring. ▶ BPA induces changes in uterine morphology and apoptosis pattern of the offspring. ▶ BPA induces a down regulation of ERα in uterine epithelial cells of the offspring. ▶ BPA administered chronically to dams modifies the reproductive cycle of the offspring. Bisphenol A (BPA) is an estrogenic agonist compound that induces changes in diverse reproductive parameters in rats. The aim of the present study was to determine the effects of BPA given in drinking water containing 10 mg/L (approximate dose 1.2 mg/kg BW/day), administered chronically to rats during pregnancy and lactation, on reproductive tract parameters of the offspring. 79.2% of the female offspring from BPA-treated mothers presented irregular estrous cycles. As compared to the control group, a significant increase in the thickness of the uterine epithelia and stroma was observed in the BPA group. Additionally, 60% of the female offspring from BPA mothers did not undergo abundant uterine epithelial apoptosis during the estrus phase of the cycle while control animals did. In addition, a down regulation of ERα expression was observed in epithelial cells on estrus day. The results indicate that BPA, when administered chronically in water beverages to dams, modifies the reproductive cycle of the offspring during young adulthood.