Dopamine susceptibility of APO-SUS rats is not per se coupled to HPA-axis activity

Abstract A synergistic relationship is thought to exist between hypothalamic–pituitary–adrenal (HPA) axis activity and dopamine neurotransmission. To test whether a high response to dopamine indeed implies a hyperactive HPA-axis, we here used Wistar rats that were selected twice independently (origi...

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Published in:Physiology & behavior 2011-02, Vol.102 (2), p.121-125
Main Authors: van Schijndel, Jessica E, van Zweeden, Martine, van Loo, Karen M.J, Lubbers, Luuk J, Pesman, Gerard J, Sweep, Fred C.G.J, Martens, Gerard J.M
Format: Article
Language:English
Subjects:
ACTH, free corticosterone
Adrenocorticotropic Hormone - metabolism
agonists
Analysis of Variance
animal models
Animals
Apomorphine
Apomorphine - pharmacology
Behavior, Animal - drug effects
Behavioral psychophysiology
Biological and medical sciences
Corticosteroid-binding globulin
Corticosterone - metabolism
corticotropin
dopamine
Dopamine - metabolism
Dopamine Agonists - pharmacology
dopamine receptors
Exploratory Behavior - drug effects
Fundamental and applied biological sciences. Psychology
Hypothalamo-Hypophyseal System - physiology
Male
Pituitary-Adrenal System - physiology
Polymorphism, Single Nucleotide - genetics
Psychiatry
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat model
Rats
Rats, Wistar
Transcortin - genetics
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Summary:Abstract A synergistic relationship is thought to exist between hypothalamic–pituitary–adrenal (HPA) axis activity and dopamine neurotransmission. To test whether a high response to dopamine indeed implies a hyperactive HPA-axis, we here used Wistar rats that were selected twice independently (original and replicate lines) for a high or low susceptibility to the dopamine receptor agonist apomorphine (so-called APO-SUS and APO-UNSUS rats, respectively). The APO-SUS rats from the original line displayed a hyperactive HPA-axis in that higher basal and stress-induced adrenocorticotropic hormone (ACTH) levels, and lower basal free-corticosterone levels were observed than those found in the original APO-UNSUS rats. In contrast, the activity of the HPA-axis in the APO-SUS rats from the replicate line did not differ from that in the replicate APO-UNSUS rats. Thus, in the APO-SUS/APO-UNSUS rat model the level of HPA-axis activity is not necessarily causally linked to dopamine responsiveness, implying that a hyperactive HPA-axis is not a prerequisite for a high dopaminergic response.
ISSN:0031-9384
1873-507X
DOI:10.1016/j.physbeh.2010.10.013