Pre- versus post-column oxidation liquid chromatography fluorescence detection of paralytic shellfish toxins

Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares th...

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Bibliographic Details
Published in:Toxicon (Oxford) 2011-03, Vol.57 (4), p.619-624
Main Authors: DeGrasse, Stacey L., van de Riet, Jeffrey, Hatfield, Robert, Turner, Andrew
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Bacteriology
Bioassay
bioassays
Biological and medical sciences
Chromatography, High Pressure Liquid
Fluorescence
Fundamental and applied biological sciences. Psychology
Liquid chromatography
Medical sciences
Mice
Microbiology
Oxidation
Oxidation-Reduction
Paralytic shellfish toxins
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Plant poisons toxicology
Saxitoxin
Saxitoxin - analysis
Shellfish
Shellfish Poisoning
Spectrometry, Fluorescence
Toxicology
Toxins
Validation
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Description
Summary:Both pre- and post-column oxidation liquid chromatography methods with fluorescence detection are available for detecting paralytic shellfish toxins. Each method has been evaluated in multiple laboratories and validated as a potential alternative to the mouse bioassay. This communication compares the advantages and limitations of both methods. For a given laboratory, the selection of either method may be based primarily on practicality and less on any deficiencies in scientific merit.
ISSN:0041-0101
1879-3150
DOI:10.1016/j.toxicon.2010.12.017