Effect of emodin on neuropathic pain transmission mediated by P2X2/3 receptor of primary sensory neurons

Research highlights ► Emodin is an active anthraquinone constituent of rhubarb extract. ► The application of emodin decreased the hyperalgesia of CCI rats and the P2X2/3 expression of L4/L5 DRG in CCI rats. ► Emodin can alleviate chronic neuropathic pain mediated by P2X2/3 receptor of primary sensor...

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Bibliographic Details
Published in:Brain research bulletin 2011-04, Vol.84 (6), p.406-413
Main Authors: Gao, Yun, Liu, Han, Deng, Libin, Zhu, Gaochun, Xu, Changshui, Li, Guilin, Liu, Shuangmei, Xie, Jinyan, Liu, Jun, Kong, Fanjun, Wu, Raoping, Li, Guodong, Liang, Shangdong
Format: Article
Language:English
Subjects:
Analgesics - pharmacology
Analgesics - therapeutic use
Animals
Emodin - pharmacology
Emodin - therapeutic use
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
Ganglia, Spinal - metabolism
Male
Neuralgia - drug therapy
Neuralgia - metabolism
Neurology
Pain Measurement
Protein Kinase Inhibitors - pharmacology
Protein Kinase Inhibitors - therapeutic use
Random Allocation
Rats
Rats, Sprague-Dawley
Receptors, Purinergic P2X2 - metabolism
Receptors, Purinergic P2X3 - metabolism
Sensory Receptor Cells - cytology
Sensory Receptor Cells - drug effects
Sensory Receptor Cells - metabolism
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Summary:Research highlights ► Emodin is an active anthraquinone constituent of rhubarb extract. ► The application of emodin decreased the hyperalgesia of CCI rats and the P2X2/3 expression of L4/L5 DRG in CCI rats. ► Emodin can alleviate chronic neuropathic pain mediated by P2X2/3 receptor of primary sensory neurons.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.01.017