Cell renewal in adjoining intestinal and tracheal epithelia of Manduca

Cell renewal continuously replaces dead or dying cells in organs such as human and insect intestinal (midgut) epithelia; in insects, control of self-renewal determines insects' responses to any of the myriad pathogens and parasites of medical and agricultural importance that enter and cross the...

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Bibliographic Details
Published in:Journal of insect physiology 2011-04, Vol.57 (4), p.487-493
Main Authors: Nardi, James B, Bee, Charles Mark, Miller, Lou Ann, Mathur, Divya, Ohlstein, Benjamin
Format: Article
Language:English
Subjects:
Animals
Cell Differentiation
Epithelial Cells - cytology
Fasciclin II
insects
Intestinal cells
Intestines - cytology
Intestines - embryology
Larva - cytology
Larva - growth & development
Manduca
Manduca - cytology
Manduca - embryology
Midgut
muscles
nerve tissue
parasites
pathogens
Regenerative cells
Stem cells
Trachea - cytology
Trachea - embryology
Tracheae
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Summary:Cell renewal continuously replaces dead or dying cells in organs such as human and insect intestinal (midgut) epithelia; in insects, control of self-renewal determines insects' responses to any of the myriad pathogens and parasites of medical and agricultural importance that enter and cross their midgut epithelia. Regenerative cells occur in the midgut epithelia of many, if not all, insects and are probably derived from a distinctive population of stem cells. The control of proliferation and differentiation of these midgut regenerative cells is assumed to be regulated by an environment of adjacent cells that is referred to as a regenerative cell niche. An antibody to fasciclin II marks cell surfaces of tracheal regenerative cells associated with rapidly growing midgut epithelia. Tracheal regenerative cells and their neighboring midgut regenerative cells proliferate and differentiate in concert during the coordinated growth of the midgut and its associated muscles, nerves and tracheal cells.
ISSN:0022-1910
1879-1611
DOI:10.1016/j.jinsphys.2011.01.008