Distinction between postoperative recurrent glioma and radiation injury using MR diffusion tensor imaging

Introduction This study aims to evaluate the differentiated effectiveness of MR diffusion tensor imaging (DTI) to postoperative recurrent glioma and radiation injury. Methods Conventional MRI and DTI examination were performed using Siemens 3.0 T MR System for patients with new contrast-enhancing le...

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Bibliographic Details
Published in:Neuroradiology 2010-12, Vol.52 (12), p.1193-1199
Main Authors: Xu, Jun-Ling, Li, Yong-Li, Lian, Jian-Min, Dou, She-wei, Yan, Feng-Shan, Wu, Hui, Shi, Da-peng
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Brain cancer
Brain Neoplasms - pathology
Brain Neoplasms - radiotherapy
Cancer surgery
Diagnosis, Differential
Diffusion Magnetic Resonance Imaging - methods
Female
Functional Neuroradiology
Glioma - pathology
Glioma - radiotherapy
Humans
Imaging
Injuries
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical diagnosis
Medical imaging
Medical sciences
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - prevention & control
Neoplasms, Radiation-Induced - etiology
Neoplasms, Radiation-Induced - pathology
Nervous system
Nervous system (semeiology, syndromes)
Nervous system as a whole
Neurology
Neuroradiology
Neurosciences
Neurosurgery
NMR
Nuclear magnetic resonance
Postoperative Care
Radiation therapy
Radiodiagnosis. Nmr imagery. Nmr spectrometry
Radiology
Treatment Outcome
Young Adult
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Summary:Introduction This study aims to evaluate the differentiated effectiveness of MR diffusion tensor imaging (DTI) to postoperative recurrent glioma and radiation injury. Methods Conventional MRI and DTI examination were performed using Siemens 3.0 T MR System for patients with new contrast-enhancing lesions at the site of treated tumor with postoperative radiotherapy. The region of interest was manually drawn on ADC and FA maps at contrast-enhancing lesion area, peri-lesion edema, and the contra-lateral normal white matter. Then ADC and FA values were measured and, the ADC ratio and FA ratio were calculated. Twenty patients with recurrent tumor and 15 with radiation injury were confirmed by histopathologic examination (23 patients) and clinical imaging follow-up (12 patients), respectively. The mean ADC ratio and FA ratio were compared between the two lesion types. Results The mean ADC ratio at contrast-enhancing lesion area was significantly lower in patients with recurrent tumor (1.34 ± 0.15) compared to that with radiation injury (1.62 ± 0.17; P  
ISSN:0028-3940
1432-1920
DOI:10.1007/s00234-010-0731-4