Antidepressant-like effects of urocortin 3 fragments

Abstract Urocortin 3 (Ucn 3) and various Ucn 3 fragments were tested with regard to antidepressive action in a modified forced swimming test following icv administration to mice. The fragment Ucn 3 (34–36) proved ineffective, whereas Ucn 3 (18–38), Ucn 3 (19–27), Ucn 3 (28–38), Ucn 3 (34–38), and Uc...

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Bibliographic Details
Published in:Brain research bulletin 2011-04, Vol.84 (6), p.414-418
Main Authors: Tanaka, M, Kádár, K, Tóth, G, Telegdy, G
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Antidepressive action
Antidepressive Agents - pharmacology
Antidepressive Agents - therapeutic use
Behavior, Animal - drug effects
Humans
Male
Mice
Molecular Sequence Data
Neurology
Neuropsychological Tests
Peptide Fragments - pharmacology
Peptide Fragments - therapeutic use
Stress, Psychological - drug therapy
Swimming
Urocortin 3 fragments
Urocortins - genetics
Urocortins - metabolism
Urocortins - pharmacology
Urocortins - therapeutic use
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Summary:Abstract Urocortin 3 (Ucn 3) and various Ucn 3 fragments were tested with regard to antidepressive action in a modified forced swimming test following icv administration to mice. The fragment Ucn 3 (34–36) proved ineffective, whereas Ucn 3 (18–38), Ucn 3 (19–27), Ucn 3 (28–38), Ucn 3 (34–38), and Ucn 3 (36–38) demonstrated antidepressive-like action by shortening the immobility time and increasing the climbing and swimming times. The shortest molecule which elicited most of the antidepressive effects was the tripeptide Ucn 3 (36–38), H-Ala-Gln-Ile-NH2 . The results indicate that the total sequence of Ucn 3 is not necessary for the antidepressive action of Ucn 3. Furthermore, the antidepresant actions of Unc3 (19–27) and Ucn 3 (36–38) can be blocked by the CRF2 receptor antagonist Astressin 2β. Establishment of the smallest active sequence of the molecule may allow the synthesis of analogs or mimetics for antidepressive drugs.
ISSN:0361-9230
1873-2747
DOI:10.1016/j.brainresbull.2011.01.016