Philadelphicalactones C and D and other cytotoxic compounds from Physalis philadelphica

[Display omitted] ► Two new and four known withanolides were isolated from Physalis philadelphica. ► The new compounds are 24-hydroxywithanolides. ► Five of the isolated compounds showed cytotoxic activity against a panel of six human cancer cell lines. ► Withaphysacarpin ( 3) showed the most potent...

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Bibliographic Details
Published in:Steroids 2011-06, Vol.76 (7), p.724-728
Main Authors: Maldonado, Emma, Pérez-Castorena, Ana L., Garcés, Consuelo, Martínez, Mahinda
Format: Article
Language:English
Subjects:
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Biological and medical sciences
Cell Line, Tumor
Cytotoxic activity
Fundamental and applied biological sciences. Psychology
Humans
Inhibitory Concentration 50
Lactones - chemistry
Lactones - isolation & purification
Lactones - pharmacology
Physalis - chemistry
Physalis philadelphica
Solanaceae
Vertebrates: endocrinology
Withanolides
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Summary:[Display omitted] ► Two new and four known withanolides were isolated from Physalis philadelphica. ► The new compounds are 24-hydroxywithanolides. ► Five of the isolated compounds showed cytotoxic activity against a panel of six human cancer cell lines. ► Withaphysacarpin ( 3) showed the most potent cytotoxicity with IC 50 values
ISSN:0039-128X
1878-5867
DOI:10.1016/j.steroids.2011.03.018