Biochemical and histological responses of Rattus novergicus (Wistar) infected by Echinostoma paraensei (Trematoda: Echinostomatidae)

Tests were performed to evaluate the biochemical alterations in Rattus norvegicus after infection by the intestinal trematode Echinostoma paraensei. The rodents received 150 metacercariae each, serum samples were collected and the parasite load was quantified weekly until the fifth week of infection...

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Bibliographic Details
Published in:Veterinary parasitology 2011-05, Vol.178 (1-2), p.86-92
Main Authors: Garcia, Juberlan S., Hooper, Cleber S., Simões, Raquel O., dos Santos, Marcos Antônio J., Maldonado, Arnaldo, Pinheiro, Jairo
Format: Article
Language:English
Subjects:
alanine transaminase
Albumin
alkaline phosphatase
Alkaline Phosphatase - blood
ALKP
Aminotransferases
Animals
Aspartate Aminotransferases - blood
aspartate transaminase
Bilirubin
blood proteins
cholestasis
Echinostoma
Echinostomiasis - blood
Echinostomiasis - immunology
Echinostomiasis - pathology
Female
gamma-Glutamyltransferase - blood
Globulin
globulins
glucose
glycogen
Hepatic function
Liver - pathology
liver function
metacercariae
parasite load
Rats
Rats, Wistar
Rattus norvegicus
trematode infections
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Summary:Tests were performed to evaluate the biochemical alterations in Rattus norvegicus after infection by the intestinal trematode Echinostoma paraensei. The rodents received 150 metacercariae each, serum samples were collected and the parasite load was quantified weekly until the fifth week of infection. The levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALKP), gamma-glutamyl transferase (GGT), bilirubin, glucose, total proteins and fractions and hepatic glycogen were determined. All the animals exposed to the metacercariae were infected in the first week and worms were recovered up to the third week after infection. The levels of AST, ALT, GGT, bilirubin and globulin rose in the first and/or second week and declined thereafter to levels near those of the control group. In contrast, the level of total proteins in the plasma fell significantly in the first week while the ALKP activity went down only in the fourth and fifth weeks in relation to the control group. There was no significant difference in the levels of albumin, glycogen and glucose. Infection by E. paraensei in R. norvegicus causes changes in the hepatic function, possibly resulting from the cholestasis produced by the partial obstruction of the bile duct by the helminths.
ISSN:0304-4017
1873-2550
DOI:10.1016/j.vetpar.2010.12.040