Synaptic Growth: Dancing with Adducin

Manipulations of the actin-capping protein adducin in Drosophila and mammalian neurons provide new insights into the mechanisms linking structural changes to synaptic plasticity and learning. Adducin regulates synaptic remodeling, providing a molecular switch that controls synaptic growth versus dis...

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Bibliographic Details
Published in:Current biology 2011-05, Vol.21 (10), p.R402-R405
Main Authors: Stevens, Robin J., Littleton, J. Troy
Format: Article
Language:English
Subjects:
Actins - metabolism
Adducin
Animals
Brain - physiology
Calmodulin-Binding Proteins - metabolism
Drosophila
Learning
Mammals
Models, Neurological
Neuronal Plasticity - physiology
Neurons
Plasticity (synaptic)
Synapses - metabolism
Synapses - physiology
Synaptogenesis
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Summary:Manipulations of the actin-capping protein adducin in Drosophila and mammalian neurons provide new insights into the mechanisms linking structural changes to synaptic plasticity and learning. Adducin regulates synaptic remodeling, providing a molecular switch that controls synaptic growth versus disassembly during plasticity.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2011.04.020