Deodorants are the leading cause of allergic contact dermatitis to fragrance ingredients

• Published in: Contact dermatitis 2011-05, Vol.64 (5), p.258-264
• Main Authors: Heisterberg, Maria V., Menné, Torkil, Andersen, Klaus E., Avnstorp, Christian, Kristensen, Berit, Kristensen, Ove, Kaaber, Knud, Laurberg, Grete, Henrik Nielsen, Niels, Sommerlund, Mette, Thormann, Jens, Veien, Niels K., Vissing, Susanne, Johansen, Jeanne D.
• Format: Article
• Language: English
• Subjects: Adult; allergic contact dermatitis; Allergic diseases; Allergies; Biological and medical sciences; clinically relevant patch tests; cosmetics; Cosmetics - adverse effects; Cosmetics industry; Denmark; Deodorants; Deodorants - adverse effects; Deodorants - chemistry; Dermatitis; Dermatitis, Allergic Contact - etiology; Domestic and cosmetic products toxicology; Eczema; Female; fragrance; Humans; Immunopathology; Male; Medical sciences; Middle Aged; Patch Tests; Perfume - adverse effects; Perfume - chemistry; Retrospective Studies; Sex Factors; Skin allergic diseases. Stinging insect allergies; Toxicology
• ISSN: 0105-1873; 1600-0536
• DOI: 10.1111/j.1600-0536.2011.01889.x

Background. Fragrances frequently cause contact allergy, and cosmetic products are the main causes of fragrance contact allergy. As the various products have distinctive forms of application and composition of ingredients, some product groups are potentially more likely to play a part in allergic reactions than others. Aim. To determine which cosmetic product groups cause fragrance allergy among Danish eczema patients. Method. This was a retrospective study based on data collected by members of the Danish Contact Dermatitis Group. Participants (N = 17716) were consecutively patch tested with fragrance markers from the European baseline series (2005–2009). Results. Of the participants, 10.1% had fragrance allergy, of which 42.1% was caused by a cosmetic product: deodorants accounted for 25%, and scented lotions 24.4%. A sex difference was apparent, as deodorants were significantly more likely to be listed as the cause of fragrance allergy in men (odds ratio 2.2) than in women. Correlation was observed between deodorants listed as the cause of allergy and allergy detected with fragrance mix II (FM II) and hydroxyisohexyl 3‐cyclohexene carboxaldehyde. Conclusion. Deodorants were the leading causes of fragrance allergy, especially among men. Seemingly, deodorants have an ‘unhealthy’ composition of the fragrance chemicals present in FM II.