Triazole and Dihydroimidazole Alkaloids from the Marine Sediment-Derived Fungus Penicillium paneum SD-44

A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopi...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2011-05, Vol.74 (5), p.1331-1334
Main Authors: Li, Chun-Shun, An, Chun-Yan, Li, Xiao-Ming, Gao, Shu-Shan, Cui, Chuan-Ming, Sun, Hao-Fen, Wang, Bin-Gui
Format: Article
Language:English
Subjects:
Alkaloids - chemistry
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Applied microbiology
Biological and medical sciences
Carboxylic Acids
Drug Screening Assays, Antitumor
Fundamental and applied biological sciences. Psychology
General pharmacology
Geologic Sediments - chemistry
Humans
Imidazoles - chemistry
Imidazoles - isolation & purification
Imidazoles - pharmacology
Medical sciences
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Molecular Structure
Penicillium - chemistry
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Quinazolinones - chemistry
Quinazolinones - isolation & purification
Quinazolinones - pharmacology
Triazoles - chemistry
Triazoles - isolation & purification
Triazoles - pharmacology
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Summary:A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1–4 were evaluated.
ISSN:0163-3864
1520-6025
DOI:10.1021/np200037z