Histiocytic sarcoma of the parotid gland region

Histiocytic sarcoma (HS) is a malignant neoplasm showing the morphological and immunophenotypic features of mature histiocytes. Reported herein is a case of HS of the parotid gland region. A 53‐year‐old woman noticed a swelling of the right preauricular area. Preoperative fine needle aspiration cyto...

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Bibliographic Details
Published in:Pathology international 2011-06, Vol.61 (6), p.373-376
Main Authors: Akiba, Jun, Harada, Hiroshi, Kawahara, Akihiko, Arakawa, Fumiko, Mihashi, Hiroyuki, Mihashi, Ryouta, Ohshima, Koichi, Yano, Hirohisa
Format: Article
Language:English
Subjects:
Antigens, CD - analysis
Chemotherapy, Adjuvant
Diagnosis, Differential
Fatal Outcome
Female
histiocytic sarcoma
Histiocytic Sarcoma - pathology
Histiocytic Sarcoma - radiotherapy
Histiocytic Sarcoma - surgery
Humans
immunohistochemical stain
Immunohistochemistry
Immunophenotyping
In Situ Hybridization
Middle Aged
parotid gland
Parotid Neoplasms - pathology
Parotid Neoplasms - radiotherapy
Parotid Neoplasms - surgery
Parotid Region - pathology
Parotid Region - surgery
Polymerase Chain Reaction
Radiotherapy, Adjuvant
Time Factors
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Summary:Histiocytic sarcoma (HS) is a malignant neoplasm showing the morphological and immunophenotypic features of mature histiocytes. Reported herein is a case of HS of the parotid gland region. A 53‐year‐old woman noticed a swelling of the right preauricular area. Preoperative fine needle aspiration cytology showed an admixture of pleomorphic atypical cells and mature lymphocytes. She underwent total parotidectomy. Grossly, the tumor was located at the parotid gland to subcutaneous tissue, and showed infiltrative growth with massive necrosis and hemorrhage. Microscopically, the tumor was composed of marked pleomorphic cells with eosinophilic cytoplasm. Bizarre multinuclear giant cells were scattered and intermingled. Tumor cells were positive for CD68 (KP‐1 and PG‐M1), CD163, S‐100 protein, CD1a, CD4 and CD31, but negative for CD3, CD20, CD21, CD79a, DEC205 and langerin, immunohistochemically. Monoclonal proliferation of B cells was not confirmed on polymerase chain reaction for IgH. The patient had recurrent lesions in the pelvis and stomach 5 months after parotidectomy and died of the disease 10 months after the operation.
ISSN:1320-5463
1440-1827
DOI:10.1111/j.1440-1827.2011.02671.x