Co-expression of plasmid-mediated quinolone resistance-qnrA1 and blaVEB-1 gene in a Providencia stuartii strain

An extended-spectrum B-lactamase (ESBL)-producing Providencia stuartii isolate was studied. A qnrA1 gene co-expressing blaVEB-1 gene was detected. Both genes were transferred to the recipient strain. The ciprofloxacin MIC of recipient strain increased tenfold. The blaVEB-1 gene persisted in microorg...

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Bibliographic Details
Published in:The New microbiologica 2011-04, Vol.34 (2), p.225-228
Main Authors: Nazik, Hasan, Bektöre, Bayhan, Öngen, Betigül, Özyurt, Mustafa, Baylan, Orhan, Haznedaroğlu, Tunçer
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - pharmacology
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Drug Resistance, Multiple, Bacterial
Enterobacteriaceae Infections - microbiology
Gene Expression Regulation, Bacterial
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Plasmids - genetics
Plasmids - metabolism
Providencia - drug effects
Providencia - genetics
Providencia - isolation & purification
Providencia - metabolism
Quinolones - pharmacology
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Summary:An extended-spectrum B-lactamase (ESBL)-producing Providencia stuartii isolate was studied. A qnrA1 gene co-expressing blaVEB-1 gene was detected. Both genes were transferred to the recipient strain. The ciprofloxacin MIC of recipient strain increased tenfold. The blaVEB-1 gene persisted in microorganisms in Turkey but it also spread with PMQR genes to other species. The combination of PMQR with multidrug resistant isolates producing ESBLs may compromise the use of valuable antibiotics. Serious efforts are necessary to detect PMQR determinants not only with common B-lactamases in widespread pathogens but also with uncommon forms that are encountered infrequently.
ISSN:1121-7138