Triggered Release from Liposomes through Magnetic Actuation of Iron Oxide Nanoparticle Containing Membranes

The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in...

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Bibliographic Details
Published in:Nano letters 2011-04, Vol.11 (4), p.1664-1670
Main Authors: Amstad, Esther, Kohlbrecher, Joachim, Müller, Elisabeth, Schweizer, Thomas, Textor, Marcus, Reimhult, Erik
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biotechnology
Condensed matter: electronic structure, electrical, magnetic, and optical properties
Condensed matter: structure, mechanical and thermal properties
Cross-disciplinary physics: materials science
rheology
Electromagnetic Fields
Exact sciences and technology
Ferric Compounds - chemistry
Ferric Compounds - radiation effects
Fundamental and applied biological sciences. Psychology
Liposomes - chemistry
Liposomes - radiation effects
Low-dimensional structures (superlattices, quantum well structures, multilayers): structure, and nonelectronic properties
Magnetic properties and materials
Materials science
Materials Testing
Membranes, Artificial
Methods of nanofabrication
Methods. Procedures. Technologies
Nanocapsules - chemistry
Nanocapsules - radiation effects
Others
Permeability - radiation effects
Pharmaceutical Preparations - administration & dosage
Pharmaceutical Preparations - chemistry
Physics
Self-assembly
Small particles and nanoscale materials
Studies of specific magnetic materials
Surfaces and interfaces
thin films and whiskers (structure and nonelectronic properties)
Various methods and equipments
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Description
Summary:The ideal nanoscale drug delivery vehicle allows control over the released dose in space and time. We demonstrate that this can be achieved by stealth liposomes comprising self-assembled superparamagnetic iron oxide nanoparticles (NPs) individually stabilized with palmityl-nitroDOPA incorporated in the lipid membrane. Alternating magnetic fields were used to control timing and dose of repeatedly released cargo from such vesicles by locally heating the membrane, which changed its permeability without major effects on the environment.
ISSN:1530-6984
1530-6992
DOI:10.1021/nl2001499