Improved diabetes control in the elderly delays global cognitive decline

• Published in: The Journal of nutrition, health & aging health & aging, 2011-06, Vol.15 (6), p.445-449
• Main Authors: Luchsinger, José A., Palmas, Walter, Teresi, J. A., Silver, S., Kong, J., Eimicke, J. P., Weinstock, R. S., Shea, S.
• Format: Article
• Language: English
• Subjects: Aged; Aging; Biological and medical sciences; Blood Pressure; Case Management; Cholesterol, LDL - blood; Cognition Disorders - blood; Cognition Disorders - prevention & control; Diabetes Complications - prevention & control; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - nursing; Diabetes. Impaired glucose tolerance; Disease Progression; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Geriatrics/Gerontology; Glycated Hemoglobin - metabolism; Humans; JNHA: Clinical Neurosciences; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Neurosciences; Nutrition; Primary Care Medicine; Quality of Life Research; Telemedicine - methods; Vertebrates: anatomy and physiology, studies on body, several organs or systems
• ISSN: 1279-7707; 1760-4788
• DOI: 10.1007/s12603-011-0057-x

Objectives To examine whether improved diabetes control is related to better cognitive outcomes. Design Randomized control trial . Setting A randomized trial of telemedicine vs. usual care in elderly persons with type 2 diabetes. Participants Participants were 2169 persons 55 years and older with type 2 diabetes from New York City and Upstate New York. Intervention The diabetes case management intervention was implemented by a diabetes nurse, via a telemedicine unit in the participant’s home, and in coordination with the primary care physician. Measurements Hemoglobin A1c (HbA1c), systolic blood pressure (SBP), and low density lipoprotein cholesterol (LDL), were measured at a baseline visit and at up to 5 annual follow-up visits. Global cognition was measured at those visits with the Comprehensive Assessment and Referral Evaluation (CARE). Result In mixed models the intervention was related to slower global cognitive decline in the intervention group (p = 0.01). Improvements in HbA1c (p = 0.03), but not SBP or LDL, mediated the effect of the intervention on cognitive decline. Conclusion Improved diabetes control in the elderly following existing guidelines through a telemedicine intervention was associated with less global cognitive decline. The main mediator of this effect seemed to be improvements in HbA1c.