Relationship Between Arrhythmogenic Pulmonary Veins and the Surrounding Atrial Substrate in Patients with Paroxysmal Atrial Fibrillation

• Published in: Journal of cardiovascular electrophysiology 2011-04, Vol.22 (4), p.405-410
• Main Authors: SUENARI, KAZUYOSHI, LIN, YENN-JIANG, CHANG, SHIH-LIN, LO, LI-WEI, HU, YU-FENG, TUAN, TA-CHUAN, HUANG, SHIH-YU, TAI, CHING-TAI, NAKANO, YUKIKO, KIHARA, YASUKI, TSAO, HSUAN-MING, WU, TSU-JUEY, CHEN, SHIH-ANN
• Format: Article
• Language: English
• Subjects: Adult; Aged; Arrhythmias, Cardiac - diagnosis; Arrhythmias, Cardiac - physiopathology; Arrhythmias, Cardiac - surgery; atrial fibrillation; Atrial Fibrillation - diagnosis; Atrial Fibrillation - physiopathology; Atrial Fibrillation - surgery; Atrial Function, Left - physiology; atrial substrate; catheter ablation; Catheter Ablation - methods; complex fractionated atrial electrograms; dominant frequency analysis; Electrocardiography - methods; Female; Follow-Up Studies; Humans; Male; Middle Aged; Pulmonary Veins - physiopathology; Pulmonary Veins - surgery
• ISSN: 1045-3873; 1540-8167
• DOI: 10.1111/j.1540-8167.2010.01932.x

Arrhythmogenic PVs and the Fibrillatory Activities. Introduction: The relationship between pulmonary veins (PVs) with atrial fibrillation (AF) initiating triggers and their surrounding atrial substrate has not been elucidated. We aimed to clarify the atrial substrate properties around the PVs. Methods and Results: Twenty‐three paroxysmal AF patients were studied with the identification of PV initiating triggers. High‐density mapping of the dominant frequency (DF, 1200 Hz) and the mean degree of the complex fractionated electrograms (CFE mean interval over 6 seconds) was evaluated in 2 zones (zone 1: < 5 mm, zone 2: 5–15 mm from the PVs) and the left atrial (LA) using a NavX system prior to the PV isolation. High‐DFs (>8 Hz) and continuous CFEs (