A Phased-Array Stimulator System for Studying Planar and Curved Cardiac Activation Wavefronts

Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted dem...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2008-01, Vol.55 (1), p.222-229
Main Authors: Abbas, Rashida A., Lin, Shien-Fong, Mashburn, David, Xu, Junkai, Wikswo, John P.
Format: Article
Language:English
Subjects:
Activation
Arrays
Cardiac conduction velocity
Cardiac Pacing, Artificial - methods
Cardiac tissue
Charge coupled devices
Computational geometry
Curvature
curved activation wavefronts
Electric Stimulation - instrumentation
Electric Stimulation - methods
Electrodes
Equipment Design
Equipment Failure Analysis
Fiber lasers
Geometrical optics
Heart
Heart Conduction System - physiopathology
Laser modes
Lasers
Mathematical models
multisite stimulation
Pacemaker, Artificial
Rabbits
Shape
Stimulators
tissue anisotropy
Transducers
Voltage
Wave fronts
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Summary:Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted demonstration experiments on isolated perfused rabbit hearts, which were stained with the voltage-sensitive dye, di-4-ANEPPS. The wavefronts were imaged using a laser and a charge-coupled device (CCD) camera. The stimulator and imaging systems have been used to characterize the relationship between wavefront velocity and fiber orientation. This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays.
ISSN:0018-9294
1558-2531
DOI:10.1109/TBME.2007.901039