Quantification of Tremor and Bradykinesia in ParkinsonE14s Disease Using a Novel Ambulatory Monitoring System

An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the forearms. An algorithm to detect and quanti...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 2007-01, Vol.54 (2)
Main Authors: Salarian, A, Russmann, H, Wider, C, Burkhard, PR, Vingerhoets, FJG, Aminian, K
Format: Article
Language:English
Online Access:Get full text
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Summary:An ambulatory system for quantification of tremor and bradykinesia in patients with Parkinson's disease (PD) is presented. To record movements of the upper extremities, a sensing units which included miniature gyroscopes, has been fixed to each of the forearms. An algorithm to detect and quantify tremor and another algorithm to quantify bradykinesia have been proposed and validated. Two clinical studies have been performed. In the first study, 10 PD patients and 10 control subjects participated in a 45-min protocol of 17 typical daily activities. The algorithm for tremor detection showed an overall sensitivity of 99.5% and a specificity of 94.2% in comparison to a video reference. The estimated tremor amplitude showed a high correlation to the Unified Parkinson's Disease Rating Scale (UPDRS) tremor subscore (e.g., r=0.87, p
ISSN:0018-9294
DOI:10.1109/TBME.2006.886670