Factors associated with severe versus mild immunotherapy-related systemic reactions: A case-referent study

Respondents with grade 3 SRs reported more frequently administering high target dose ranges of standardized cat extract (2000-4000 biologic allergen units Fel d 1; 62.9% vs 56.4%) and higher dose ranges of standardized grass pollen (2000-4000 biologic allergen units; 74.3% vs 66.7%) than control cli...

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Bibliographic Details
Published in:Journal of allergy and clinical immunology 2011-05, Vol.127 (5), p.1298-1300
Main Authors: Liss, Gary M., MD, MS, Murphy-Berendts, Karen, BS, Epstein, Tolly, MD, MS, Bernstein, David I., MD
Format: Article
Language:English
Subjects:
Allergens - administration & dosage
Allergens - adverse effects
Allergens - immunology
Allergies
Allergy and Immunology
Anaphylaxis - etiology
Anaphylaxis - mortality
Asthma
Biological and medical sciences
Case-Control Studies
Desensitization, Immunologic - adverse effects
Desensitization, Immunologic - methods
Desensitization, Immunologic - mortality
Drug dosages
Drug-Related Side Effects and Adverse Reactions - epidemiology
Drug-Related Side Effects and Adverse Reactions - mortality
Drug-Related Side Effects and Adverse Reactions - physiopathology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
Immunology
Immunopathology
Immunotherapy
Medical sciences
Practice Patterns, Physicians
Risk Factors
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Surveillance
Surveys and Questionnaires
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Items that cite this one
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Summary:Respondents with grade 3 SRs reported more frequently administering high target dose ranges of standardized cat extract (2000-4000 biologic allergen units Fel d 1; 62.9% vs 56.4%) and higher dose ranges of standardized grass pollen (2000-4000 biologic allergen units; 74.3% vs 66.7%) than control clinics, although these trends were not significant. Because 1 of the grade 3 respondents and none of grade 1 respondents reported routinely prescribing doses of house dust mite below the recommended range (
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2010.12.1086