Toxicity of CdTe Quantum Dots in Bacterial Strains

Contradictory results on quantum dot cytotoxicity exist for many types of biological systems, especially microorganisms. In this study, we compare the cytotoxicity of CdTe quantum dots (QDs) to four very different environmental bacterial strains, giving quantitative models of the growth curves for e...

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Bibliographic Details
Published in:IEEE transactions on nanobioscience 2009-03, Vol.8 (1), p.58-64
Main Authors: Dumas, E.-M., Ozenne, V., Mielke, R.E., Nadeau, J.L.
Format: Magazinearticle
Language:English
Subjects:
Apoptosis - drug effects
Bacteria
Bacterial Physiological Phenomena - drug effects
Biological system modeling
Biological systems
Cadmium Compounds - toxicity
Capacitive sensors
CdTe
Cell Proliferation - drug effects
Cell Survival - drug effects
Electrical resistance measurement
Electron microscopy
Immune system
Microorganisms
Nanoparticles
Organisms
quantum dot (QD)
Quantum Dots
reactive oxygen species (ROS)
Reactive Oxygen Species - metabolism
Species Specificity
Tellurium - toxicity
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Summary:Contradictory results on quantum dot cytotoxicity exist for many types of biological systems, especially microorganisms. In this study, we compare the cytotoxicity of CdTe quantum dots (QDs) to four very different environmental bacterial strains, giving quantitative models of the growth curves for exposed organisms. The mechanisms of toxicity are explored by measuring reactive oxygen species generation by the QDs alone and investigating the oxidative damage to mutant bacteria especially sensitive to ROS. Electron microscopic examination also reveals factors that may contribute to resistance to nanoparticles in some strains.
ISSN:1536-1241
1558-2639
DOI:10.1109/TNB.2009.2017313