Cortactin in Breast Cancer: Analysis with Tissue Microarray

• Published in: Anticancer research 2011, Vol.31 (1), p.293-297
• Main Authors: SHEEN-CHEN, Shyr-Ming, HUANG, Chun-Ying, LIU, Yu-Yin, HUANG, Chao-Cheng, TANG, Rei-Ping
• Format: Article
• Language: English
• Subjects: Adult; Aged; Biological and medical sciences; Breast Neoplasms - metabolism; Breast Neoplasms - pathology; Cortactin - metabolism; Female; Gynecology. Andrology. Obstetrics; Humans; Immunoenzyme Techniques; Lymph Nodes - pathology; Mammary gland diseases; Medical sciences; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Prognosis; Receptors, Estrogen - metabolism; Survival Rate; Tissue Array Analysis; Tumors
• ISSN: 0250-7005; 1791-7530

Tissue microarray (TMA) allows the rapid immunohistochemical analysis of thousands of tissue samples in a parallel fashion. This study was designed to analyze the cortactin status in breast cancer using TMA and to investigate the relationship of cortactin status to breast cancer biology. Archival tissue specimens from 99 patients with primary invasive breast cancer were selected. The cortactin expression was analyzed by TMA. Age, estrogen receptor status, histological grading and TNM staging data were also collected. There were 23 patients (23.2%) with low (+) expression of cortactin, 60 patients (60.6%) with intermediate (++) expression and 16(16.2%) with strong (+++) expression. There was no significant relationship between cortactin expression and age, histological grading, primary tumor staging, lymph node status, estrogen receptor and TNM stage. By multivariate analysis, estrogen receptor status and TNM staging were found to be significantly related to the overall five-year survival rate. Cortactin expression failed to demonstrate a prognostic value for patients with breast cancer.