Monitoring of Bordetella isolates circulating in Saint Petersburg, Russia between 2001 and 2009

Bordetella isolates in the Saint Petersburg region have been monitored since 1998. Over the past ten years, concomitant with the increase in pertussis whole-cell vaccine coverage, the incidence of whooping cough has decreased. However, this decrease exists only for Bordetella pertussis infections, a...

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Bibliographic Details
Published in:Research in microbiology 2010-12, Vol.161 (10), p.810-815
Main Authors: Kurova, Natalia, Njamkepo, Elisabeth, Brun, Delphine, Tseneva, Galina, Guiso, Nicole
Format: Article
Language:English
Subjects:
Bacterial Typing Techniques
Bordetella
Bordetella Infections - epidemiology
Bordetella Infections - microbiology
Bordetella parapertussis
Bordetella parapertussis - classification
Bordetella parapertussis - isolation & purification
Bordetella parapertussis isolates
Bordetella pertussis
Bordetella pertussis - classification
Bordetella pertussis - isolation & purification
Child
Child, Preschool
Clinical isolates
Cluster Analysis
Digestion
DNA
DNA sequencing
Electrophoresis, Gel, Pulsed-Field
Humans
Immunity
Immunoblotting
Incidence
Infant
Infection
Molecular Epidemiology
Molecular Typing
Pertussis
Pulsed-field gel electrophoresis
Russia - epidemiology
Sequence Analysis, DNA
Serotyping
St Petersburg
Vaccines
Virulence
Virulence Factors - genetics
Whooping cough
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Summary:Bordetella isolates in the Saint Petersburg region have been monitored since 1998. Over the past ten years, concomitant with the increase in pertussis whole-cell vaccine coverage, the incidence of whooping cough has decreased. However, this decrease exists only for Bordetella pertussis infections, as the incidence of Bordetella parapertussis confirmed cases has remained stable, suggesting that pertussis-vaccine-induced immunity is not protective against parapertussis, as expected. B. pertussis and B. parapertussis clinical isolates were analyzed using serotyping, immunoblotting, pulsed-field gel electrophoresis of chromosomal DNA (after digestion with XbaI) and sequencing of virulence genes. The bacterial population is now similar to that observed in other European countries.
ISSN:0923-2508
1769-7123
DOI:10.1016/j.resmic.2010.09.013