Inhibition of cell growth by Stellera chamaejasme extract is associated with induction of autophagy and differentiation in chronic leukemia K562 cells

Stellera chamaejasme has been used as a therapeutic plant for treatment of various inflammatory diseases and solid tumors. Our study was particularly interested in the differentiation inducing activity of the aerial parts of S.chamaejasme using human chronic leukemia cell line K562. The ethanol extr...

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Bibliographic Details
Published in:Journal of bioscience and bioengineering 2010-08, Vol.110 (2), p.262-268
Main Authors: Tsolmon, Soninkhishig, Han, Junkyu, Isoda, Hiroko
Format: Article
Language:English
Subjects:
Autophagy
Autophagy - drug effects
Biological and medical sciences
Biotechnology
Cell cycle
Cell Cycle - drug effects
Cell Differentiation - drug effects
Cell Proliferation - drug effects
Differentiation
Fundamental and applied biological sciences. Psychology
Humans
K562 Cells
Leukemia
Plant Extracts - pharmacology
Stellaria - chemistry
Stellera chamaejasme
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Summary:Stellera chamaejasme has been used as a therapeutic plant for treatment of various inflammatory diseases and solid tumors. Our study was particularly interested in the differentiation inducing activity of the aerial parts of S.chamaejasme using human chronic leukemia cell line K562. The ethanol extract has been shown to be highly cytotoxic against K562 cells at > 0.008% (v/v) doses. Cell cycle arrest at G 0/G 1 phase, not detectable DNA fragmentation as well as positive staining with acridine orange and expression of beclin-1 protein in the treated cells led as to detect autophagic cell death during the plant extract treatment of K562 cells. Moreover, differentiation marker CD11b was also expressed in the treated cells.
ISSN:1389-1723
1347-4421
DOI:10.1016/j.jbiosc.2010.02.006