New developments in dry powder pulmonary vaccine delivery

Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications a...

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Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2011-04, Vol.29 (4), p.191-198
Main Authors: Sou, Tomás, Meeusen, Els N, de Veer, Michael, Morton, David A.V, Kaminskas, Lisa M, McIntosh, Michelle P
Format: Article
Language:English
Subjects:
Administration, Inhalation
Animals
Antigens
Atoms & subatomic particles
Biological and medical sciences
Biotechnology
Drug Delivery Systems - methods
Dry Powder Inhalers
Drying
Formulations
Fundamental and applied biological sciences. Psychology
General pharmacology
Health. Pharmaceutical industry
Humans
Immune response
Immunization
Immunization - methods
Industrial applications and implications. Economical aspects
Industrialized nations
Internal Medicine
Medical personnel
Medical sciences
Membranes
Miscellaneous
Pandemics
Particle size
Permeability
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Recognition
spray drying
Stability
Trends
Tuberculosis
Vaccines
Vaccines - administration & dosage
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Description
Summary:Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing cold-chain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery.
ISSN:0167-7799
1879-3096
DOI:10.1016/j.tibtech.2010.12.009