Label-Free Colorimetric Detection of Nucleic Acids Based on Target-Induced Shielding Against the Peroxidase-Mimicking Activity of Magnetic Nanoparticles

DNA, a biological shield: A new and simple colorimetric strategy for the detection of nucleic acids relies on target‐DNA‐induced shielding against the peroxidase‐mimicking activity of magnetic nanoparticles. The viability of this simple yet efficient colorimetric detection system is demonstrated by...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-06, Vol.7 (11), p.1521-1525
Main Authors: Park, Ki Soo, Kim, Moon Il, Cho, Dae-Yeon, Park, Hyun Gyu
Format: Article
Language:English
Subjects:
Chlamydia - genetics
colorimetric biosensors
Colorimetry - methods
DNA, Bacterial - analysis
magnetic nanoparticles
Magnetics
Nanoparticles - chemistry
nucleic acids
Nucleic Acids - analysis
Peroxidase - metabolism
peroxidase mimetics
shielding action
Solutions
Spectrophotometry, Ultraviolet
Staining and Labeling
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Summary:DNA, a biological shield: A new and simple colorimetric strategy for the detection of nucleic acids relies on target‐DNA‐induced shielding against the peroxidase‐mimicking activity of magnetic nanoparticles. The viability of this simple yet efficient colorimetric detection system is demonstrated by its application to the diagnosis of the Chlamydia trachomatis pathogen using a human urine sample.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201001886