Exocytosis of Mesoporous Silica Nanoparticles from Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting

The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The...

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Bibliographic Details
Published in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-06, Vol.7 (11), p.1526-1532
Main Authors: Slowing, Igor I., Vivero-Escoto, Juan L., Zhao, Yannan, Kandel, Kapil, Peeraphatdit, Chorthip, Trewyn, Brian G., Lin, Victor S.-Y.
Format: Article
Language:English
Subjects:
cancer
Endothelial Cells - cytology
Endothelial Cells - metabolism
enhanced permeability and retention
Exocytosis
Flow Cytometry
Fluorescein-5-isothiocyanate - metabolism
Fluorescence
HeLa Cells
Humans
Intracellular Space - metabolism
Magnetics
mesoporous silica nanoparticles
Microscopy, Confocal
Nanoparticles - chemistry
Nanoparticles - ultrastructure
Nanotechnology - methods
Porosity
protein sequestration
Proteins - metabolism
Silicon Dioxide - metabolism
Umbilical Veins - cytology
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Summary:The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The exo­cytosis of highly adsorbent magnetic MSNs proves to be useful as a means for harvesting biomolecules from living cells.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.201002077