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Exocytosis of Mesoporous Silica Nanoparticles from Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting

The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The...

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Published in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2011-06, Vol.7 (11), p.1526-1532
Main Authors:	Slowing, Igor I., Vivero-Escoto, Juan L., Zhao, Yannan, Kandel, Kapil, Peeraphatdit, Chorthip, Trewyn, Brian G., Lin, Victor S.-Y.
Format:	Article
Language:	English
Subjects:	cancer Endothelial Cells - cytology Endothelial Cells - metabolism enhanced permeability and retention Exocytosis Flow Cytometry Fluorescein-5-isothiocyanate - metabolism Fluorescence HeLa Cells Humans Intracellular Space - metabolism Magnetics mesoporous silica nanoparticles Microscopy, Confocal Nanoparticles - chemistry Nanoparticles - ultrastructure Nanotechnology - methods Porosity protein sequestration Proteins - metabolism Silicon Dioxide - metabolism Umbilical Veins - cytology
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creator	Slowing, Igor I. Vivero-Escoto, Juan L. Zhao, Yannan Kandel, Kapil Peeraphatdit, Chorthip Trewyn, Brian G. Lin, Victor S.-Y.
description	The exocytosis of mesoporous silica nanoparticles (MSNs) from mammalian cells is demonstrated for the first time. The differences in the degree of exocytosis of MSNs between healthy and cancer cells are shown to be responsible for the asymmetric transfer of the particles between both cell types. The exocytosis of highly adsorbent magnetic MSNs proves to be useful as a means for harvesting biomolecules from living cells.
doi_str_mv	10.1002/smll.201002077
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subjects	cancer Endothelial Cells - cytology Endothelial Cells - metabolism enhanced permeability and retention Exocytosis Flow Cytometry Fluorescein-5-isothiocyanate - metabolism Fluorescence HeLa Cells Humans Intracellular Space - metabolism Magnetics mesoporous silica nanoparticles Microscopy, Confocal Nanoparticles - chemistry Nanoparticles - ultrastructure Nanotechnology - methods Porosity protein sequestration Proteins - metabolism Silicon Dioxide - metabolism Umbilical Veins - cytology
title	Exocytosis of Mesoporous Silica Nanoparticles from Mammalian Cells: From Asymmetric Cell-to-Cell Transfer to Protein Harvesting
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