The environment and schizophrenia

Psychotic syndromes can be understood as disorders of adaptation to social context. Although heritability is often emphasized, onset is associated with environmental factors such as early life adversity, growing up in an urban environment, minority group position and cannabis use, suggesting that ex...

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Bibliographic Details
Published in:Nature (London) 2010-11, Vol.468 (7321), p.203-212
Main Authors: van Os, Jim, Kenis, Gunter, Rutten, Bart P. F
Format: Article
Language:English
Subjects:
631/378/2645
692/699/476/1799
704/158/1469
706/689/477
Animals
Care and treatment
Cities
Cognition Disorders - complications
Cognition Disorders - etiology
Data collection
Diagnosis
Drug use
Environment
Environmental factors
Genes
Genetic aspects
Genetic Predisposition to Disease
Genetics
Humanities and Social Sciences
Humans
Marijuana
Marijuana Smoking - adverse effects
Medical imaging
Mental disorders
Mental health
Minority & ethnic groups
Minority Groups
multidisciplinary
Personality disorders
perspective
Phenotype
Psychotic Disorders - etiology
Psychotic Disorders - genetics
Psychotic Disorders - physiopathology
Psychotic Disorders - psychology
Schizophrenia
Schizophrenia - etiology
Schizophrenia - genetics
Schizophrenia - physiopathology
Science
Science (multidisciplinary)
Social aspects
Stress, Psychological
Substance-Related Disorders - complications
Translational Medical Research
Twins
Urban environments
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Description
Summary:Psychotic syndromes can be understood as disorders of adaptation to social context. Although heritability is often emphasized, onset is associated with environmental factors such as early life adversity, growing up in an urban environment, minority group position and cannabis use, suggesting that exposure may have an impact on the developing 'social' brain during sensitive periods. Therefore heritability, as an index of genetic influence, may be of limited explanatory power unless viewed in the context of interaction with social effects. Longitudinal research is needed to uncover gene-environment interplay that determines how expression of vulnerability in the general population may give rise to more severe psychopathology.
ISSN:0028-0836
1476-4687
DOI:10.1038/nature09563