Is There an Association Between Low-to-Moderate Alcohol Consumption and Risk of Cognitive Decline?

The authors evaluated the association of low-to-moderate alcohol consumption with risk of cognitive decline in a census-based cohort study of men and women aged ≥55 years conducted in Zaragoza, Spain (1994–1999). Participants free of dementia at baseline (N = 3,888) were examined after 2.5 and 4.5 y...

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Bibliographic Details
Published in:American journal of epidemiology 2010-09, Vol.172 (6), p.708-716
Main Authors: Lobo, Elena, Dufouil, Carole, Marcos, Guillermo, Quetglas, Bernardo, Saz, Pedro, Guallar, Eliseo, Lobo, Antonio
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Aging
alcohol drinking
Alcohol Drinking - adverse effects
Alcohol Drinking - epidemiology
Alcohol use
Biological and medical sciences
cognition
Cognition Disorders - chemically induced
Cognition Disorders - epidemiology
Cognitive psychology
Cohort Studies
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Dementia
Epidemiology
Female
follow-up studies
General aspects
Health Status
Humans
Male
Medical sciences
Mental Status Schedule
Middle Aged
Miscellaneous
Neurology
Public health. Hygiene
Public health. Hygiene-occupational medicine
risk
Risk factors
Smoking
Studies
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Summary:The authors evaluated the association of low-to-moderate alcohol consumption with risk of cognitive decline in a census-based cohort study of men and women aged ≥55 years conducted in Zaragoza, Spain (1994–1999). Participants free of dementia at baseline (N = 3,888) were examined after 2.5 and 4.5 years of follow-up. Information on alcohol intake was collected with the EURODEM Risk Factors Questionnaire and the History and Aetiology Schedule. The study endpoint was severe cognitive decline, defined as loss of ≥1 point/year on the Mini-Mental State Examination or a diagnosis of incident dementia (Diagnostic and Statistical Manual of Mental Disorders: DSM-IV, Text Revision criteria). Compared with those for abstainers, the multivariate-adjusted odds ratios for severe cognitive decline for male drinkers of
ISSN:0002-9262
1476-6256
DOI:10.1093/aje/kwq187